ENSMUSG00000036123


Mus musculus

Features
Gene ID: ENSMUSG00000036123
  
Biological name :Slc9a3
  
Synonyms : G3X939 / Slc9a3 / Sodium/hydrogen exchanger 3
  
Possible biological names infered from orthology : P48764 / solute carrier family 9 member A3
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 74121457
Gene end: 74169442
  
Corresponding Affymetrix probe sets: 10406176 (MoGene1.0st)   1432771_at (Mouse Genome 430 2.0 Array)   1441236_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038142
Ensembl peptide - ENSMUSP00000152682
Ensembl peptide - ENSMUSP00000153255
NCBI entrez gene - 105243     See in Manteia.
MGI - MGI:105064
RefSeq - XM_006517022
RefSeq - NM_001081060
RefSeq - XM_006517021
RefSeq Peptide - NP_001074529
swissprot - G3X939
swissprot - A0A286YD40
Ensembl - ENSMUSG00000036123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc9a3.1ENSDARG00000058498Danio rerio
 slc9a3.2ENSDARG00000036722Danio rerio
 SLC9A3ENSGALG00000039738Gallus gallus
 P48764ENSG00000066230Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc9a5 / solute carrier family 9 (sodium/hydrogen exchanger), member 5 / Q14940* / solute carrier family 9 member A5*ENSMUSG0000001478652
Slc9a2 / solute carrier family 9 (sodium/hydrogen exchanger), member 2 / Q9UBY0* / solute carrier family 9 member A2*ENSMUSG0000002606236
Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*ENSMUSG0000002885434
Q8BUE1 / Slc9a4 / Sodium/hydrogen exchanger 4 / Q6AI14* / solute carrier family 9 member A4*ENSMUSG0000002606533
Q8BLV3 / Slc9a7 / Sodium/hydrogen exchanger 7 / Q96T83* / solute carrier family 9 member A7*ENSMUSG0000003734119
Q8BZ00 / Slc9a9 / Sodium/hydrogen exchanger 9 / Q8IVB4* / solute carrier family 9 member A9*ENSMUSG0000003112918
Slc9a6 / Mus musculus solute carrier family 9 (sodium/hydrogen exchanger), member 6 (Slc9a6), transcript variant 2, mRNA. / Q92581* / solute carrier family 9 member A6*ENSMUSG0000006068118
Q8R4D1 / Slc9a8 / Sodium/hydrogen exchanger 8 / Q9Y2E8* / solute carrier family 9 member A8*ENSMUSG0000003946317


Protein motifs (from Interpro)
Interpro ID Name
 IPR004709  Na+/H+ exchanger
 IPR006153  Cation/H+ exchanger
 IPR011256  Regulatory factor, effector binding domain superfamily
 IPR018410  Na+/H+ exchanger, isoforms 3/5
 IPR018422  Cation/H+ exchanger, CPA1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport IDA
 biological_processGO:0006885 regulation of pH IDA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 biological_processGO:0098719 sodium ion import across plasma membrane IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IDA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015299 solute:proton antiporter activity IEA
 molecular_functionGO:0015385 sodium:proton antiporter activity ISO
 molecular_functionGO:0015386 potassium:proton antiporter activity IBA
 molecular_functionGO:0030165 PDZ domain binding IDA


Pathways (from Reactome)
Pathway description
Sodium/Proton exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000466 esophageal epithelium hyperplasia "increased cell number in the epithelial layer of the esophagus" [J:47225]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0003027 abnormal blood pH regulation "anomaly in the function of the buffer systems of the blood in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the blood, as measured by the concentration of the hydrogen ion" [RGD:Rat Genome Database submission, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0006423 dilated rete testis "an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0009140 dilated efferent ductules of testis "an expansion in the volume or area of the lumen of the small seminal ducts that lead from the testis to the head of the epididymis, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0010108 abnormal renal water reabsorption "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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