ENSMUSG00000036622


Mus musculus

Features
Gene ID: ENSMUSG00000036622
  
Biological name :Atp13a2
  
Synonyms : Atp13a2 / Cation-transporting ATPase 13A2 / Q9CTG6
  
Possible biological names infered from orthology : ATPase 13A2 / Q9NQ11
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 140986873
Gene end: 141007330
  
Corresponding Affymetrix probe sets: 10509868 (MoGene1.0st)   1428340_s_at (Mouse Genome 430 2.0 Array)   1452746_at (Mouse Genome 430 2.0 Array)   1452747_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132183
Ensembl peptide - ENSMUSP00000039648
Ensembl peptide - ENSMUSP00000126461
NCBI entrez gene - 74772     See in Manteia.
MGI - MGI:1922022
RefSeq - XM_017320424
RefSeq - NM_001164366
RefSeq - NM_029097
RefSeq - XM_006539236
RefSeq - XM_006539237
RefSeq Peptide - NP_083373
RefSeq Peptide - NP_001157838
swissprot - E9Q2A4
swissprot - Q9CTG6
swissprot - E9PYX5
Ensembl - ENSMUSG00000036622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp13a2ENSDARG00000061890Danio rerio
 ATP13A2ENSGALG00000003774Gallus gallus
 Q9NQ11ENSG00000159363Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5XF89 / Atp13a3 / Probable cation-transporting ATPase 13A3 / Q9H7F0* / ATPase 13A3*ENSMUSG0000002253341
Atp13a4 / ATPase 13A4 / Q4VNC1*ENSMUSG0000003809438
Q3TYU2 / Atp13a5 / Probable cation-transporting ATPase 13A5 / Q4VNC0* / ATPase 13A5*ENSMUSG0000004893938


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006544  P-type ATPase, subfamily V
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0006882 cellular zinc ion homeostasis IEA
 biological_processGO:0010821 regulation of mitochondrion organization IEA
 biological_processGO:0016241 regulation of macroautophagy IEA
 biological_processGO:0016243 regulation of autophagosome size IEA
 biological_processGO:0033157 regulation of intracellular protein transport NAS
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0052548 regulation of endopeptidase activity IEA
 biological_processGO:0055069 zinc ion homeostasis IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071287 cellular response to manganese ion IEA
 biological_processGO:0097734 extracellular exosome biogenesis IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1902047 polyamine transmembrane transport IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1905037 autophagosome organization IEA
 biological_processGO:1905123 regulation of glucosylceramidase activity IMP
 biological_processGO:1905165 regulation of lysosomal protein catabolic process IMP
 biological_processGO:1990938 peptidyl-aspartic acid autophosphorylation IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 cellular_componentGO:1905103 integral component of lysosomal membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IEA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Fgd5tm3(cre/ERT2)Djr/Fgd5tm3(cre/ERT2)Djr
Genetic Background: involves: C57BL/6NTac

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fgd5tm3(cre/ERT2)Djr/Fgd5tm3(cre/ERT2)Djr
Genetic Background: involves: C57BL/6NTac

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgd5tm3(cre/ERT2)Djr/Fgd5tm3(cre/ERT2)Djr
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Sncatm1Wtd/Sncatm1Wtd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Tg(Prnp-SNCA*A53T)83Vle/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd
Genetic Background: involves: 129 * C57BL/6

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd
Genetic Background: involves: 129 * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd
Genetic Background: involves: 129 * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgd5tm3(cre/ERT2)Djr/Fgd5tm3(cre/ERT2)Djr
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Sncatm1Wtd/Sncatm1Wtd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Tg(Prnp-SNCA*A53T)83Vle/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgd5tm3(cre/ERT2)Djr/Fgd5tm3(cre/ERT2)Djr
Genetic Background: involves: C57BL/6NTac

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd
Genetic Background: involves: 129 * C57BL/6

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd
Genetic Background: involves: 129 * C57BL/6

 MP:0013522 decreased memory-marker CD4-positive NK T cell number "reduction in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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