ENSMUSG00000036639


Mus musculus

Features
Gene ID: ENSMUSG00000036639
  
Biological name :Nudt1
  
Synonyms : nudix (nucleoside diphosphate linked moiety X)-type motif 1 / Nudt1 / P53368
  
Possible biological names infered from orthology : nudix hydrolase 1 / P36639
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 140321656
Gene end: 140338137
  
Corresponding Affymetrix probe sets: 10526972 (MoGene1.0st)   1449349_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106451
Ensembl peptide - ENSMUSP00000106450
Ensembl peptide - ENSMUSP00000143140
Ensembl peptide - ENSMUSP00000059983
Ensembl peptide - ENSMUSP00000071778
Ensembl peptide - ENSMUSP00000106449
NCBI entrez gene - 17766     See in Manteia.
MGI - MGI:109280
RefSeq - XM_006504657
RefSeq - NM_001356583
RefSeq - NM_001356584
RefSeq - NM_008637
RefSeq - XM_006504655
RefSeq - XM_006504656
RefSeq Peptide - NP_032663
RefSeq Peptide - NP_001343514
RefSeq Peptide - NP_001343513
RefSeq Peptide - NP_001343512
swissprot - P53368
swissprot - D3YWH7
swissprot - A0A0G2JFE5
Ensembl - ENSMUSG00000036639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nudt1ENSDARG00000030573Danio rerio
 NUDT1ENSGALG00000004245Gallus gallus
 NUDT1ENSG00000106268Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000086  NUDIX hydrolase domain
 IPR003563  7,8-dihydro-8-oxoguanine triphosphatase
 IPR015797  NUDIX hydrolase-like domain superfamily
 IPR020084  NUDIX hydrolase, conserved site
 IPR020476  NUDIX hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006195 purine nucleotide catabolic process ISO
 biological_processGO:0006203 dGTP catabolic process ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0042262 DNA protection ISO
 biological_processGO:0046061 dATP catabolic process ISS
 biological_processGO:0046686 response to cadmium ion IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030515 snoRNA binding IDA
 molecular_functionGO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity ISO
 molecular_functionGO:0036219 GTP diphosphatase activity ISO
 molecular_functionGO:0044713 2-hydroxy-adenosine triphosphate pyrophosphatase activity ISO
 molecular_functionGO:0044714 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047693 ATP diphosphatase activity ISO


Pathways (from Reactome)
Pathway description
Phosphate bond hydrolysis by NUDT proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nudt1tm1Tts/Nudt1tm1Tts
Genetic Background: B6.129S-Nudt1tm1Tts

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010947 abnormal single-strand DNA break repair "anomaly in the process of repair of single strand breaks in DNA; repair of such breaks is mediated by the same enzyme systems as are used in base excision repair" [GO:0000012]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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