ENSMUSG00000036781


Mus musculus

Features
Gene ID: ENSMUSG00000036781
  
Biological name :Rps27l
  
Synonyms : Q6ZWY3 / ribosomal protein S27-like / Rps27l
  
Possible biological names infered from orthology : Q71UM5
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: C
Gene start: 66946086
Gene end: 66949516
  
Corresponding Affymetrix probe sets: 10586604 (MoGene1.0st)   1423254_x_at (Mouse Genome 430 2.0 Array)   1435429_x_at (Mouse Genome 430 2.0 Array)   1450925_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120518
Ensembl peptide - ENSMUSP00000046016
Ensembl peptide - ENSMUSP00000115242
Ensembl peptide - ENSMUSP00000118963
NCBI entrez gene - 67941     See in Manteia.
MGI - MGI:1915191
RefSeq - XM_017313541
RefSeq - NM_001311101
RefSeq - NM_026467
RefSeq Peptide - NP_001298030
RefSeq Peptide - NP_080743
swissprot - Q6ZWY3
swissprot - D3YYB0
swissprot - F6S6Q3
swissprot - D6RH49
Ensembl - ENSMUSG00000036781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RPS27LENSGALG00000034177Gallus gallus
 Q71UM5ENSG00000185088Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZWU9 / Rps27rt / ribosomal protein S27, retrogeneENSMUSG0000005062171
Rps27 / Q6ZWU9 / 40S ribosomal protein S27 / P42677* / ribosomal protein S27*ENSMUSG0000009073371


Protein motifs (from Interpro)
Interpro ID Name
 IPR000592  Ribosomal protein S27e
 IPR011332  Zinc-binding ribosomal protein
 IPR023407  Ribosomal protein S27e, zinc-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000028 ribosomal small subunit assembly IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0045727 positive regulation of translation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit IBA
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0008494 translation activator activity IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129 * C57BL/6N

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129 * C57BL/6N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129 * C57BL/6N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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