ENSMUSG00000037111


Mus musculus

Features
Gene ID: ENSMUSG00000037111
  
Biological name :Setd7
  
Synonyms : Histone-lysine N-methyltransferase SETD7 / Q8VHL1 / Setd7
  
Possible biological names infered from orthology : Q8WTS6 / SET domain containing lysine methyltransferase 7
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: C
Gene start: 51515319
Gene end: 51560879
  
Corresponding Affymetrix probe sets: 10498064 (MoGene1.0st)   1423003_at (Mouse Genome 430 2.0 Array)   1435437_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043492
NCBI entrez gene - 73251     See in Manteia.
MGI - MGI:1920501
RefSeq - NM_080793
RefSeq Peptide - NP_542983
swissprot - Q8VHL1
Ensembl - ENSMUSG00000037111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setd7ENSDARG00000038858Danio rerio
 SETD7ENSGALG00000009800Gallus gallus
 SETD7ENSG00000145391Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR003409  MORN motif
 IPR017155  Histone-lysine N-methyltransferase, SET


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0018022 peptidyl-lysine methylation IDA
 biological_processGO:0018026 peptidyl-lysine monomethylation IEA
 biological_processGO:0018027 peptidyl-lysine dimethylation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051570 regulation of histone H3-K9 methylation IDA
 biological_processGO:0070828 heterochromatin organization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity ISO


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0002333 abnormal lung compliance "anomalous pulmonary volume change per unit pressure change " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Setd7tm1Frga/Setd7+
Genetic Background: involves: 129 * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0008737 abnormal spleen physiology "any anomaly in the function of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Setd7tm1Frga/Setd7+
Genetic Background: involves: 129 * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Setd7tm1Frga/Setd7+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Setd7tm1.1Ital/Setd7tm1.1Ital
Genetic Background: involves: C57BL/6 * CBA

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Setd7tm1Frga/Setd7+
Genetic Background: involves: 129 * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0013258 abnormal extracellular matrix morphology "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]
Show

Allelic Composition: Setd7tm1.1Ital/Setd7tm1.1Ital
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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