ENSMUSG00000037214


Mus musculus

Features
Gene ID: ENSMUSG00000037214
  
Biological name :Thap1
  
Synonyms : Q8CHW1 / Thap1 / THAP domain-containing protein 1
  
Possible biological names infered from orthology : Q9NVV9 / THAP domain containing 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 26158141
Gene end: 26164151
  
Corresponding Affymetrix probe sets: 10571106 (MoGene1.0st)   1429282_at (Mouse Genome 430 2.0 Array)   1455003_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121153
Ensembl peptide - ENSMUSP00000042464
NCBI entrez gene - 73754     See in Manteia.
MGI - MGI:1921004
RefSeq - NM_199042
RefSeq - XM_006509202
RefSeq Peptide - NP_950243
swissprot - D3YTK5
swissprot - Q8CHW1
Ensembl - ENSMUSG00000037214
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thap1ENSDARG00000059020Danio rerio
 THAP1ENSGALG00000015385Gallus gallus
 THAP1ENSG00000131931Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Thap2 / Q9D305 / THAP domain-containing protein 2 / AC073612.1*ENSMUSG0000002013731
Thap4 / Q6P3Z3 / THAP domain-containing protein 4 / Q8WY91* / THAP domain containing 4*ENSMUSG0000002627931
Thap3 / Q8BJ25 / THAP domain containing, apoptosis associated protein 3 / Q8WTV1* / THAP domain containing 3*ENSMUSG0000003975929


Protein motifs (from Interpro)
Interpro ID Name
 IPR006612  THAP-type zinc finger
 IPR026516  THAP domain-containing protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.2Meeh/Thap1+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

 MP:0009980 abnormal cerebellum dentate nucleus morphology "any structural anomaly of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.2Meeh/Thap1+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

 MP:0011877 absent liver "absence of the bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [MGI:Colin_McKerlie]
Show

Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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