ENSMUSG00000037336


Mus musculus

Features
Gene ID: ENSMUSG00000037336
  
Biological name :Mfsd2b
  
Synonyms : Major facilitator superfamily domain-containing protein 2B / Mfsd2b / Q3T9M1
  
Possible biological names infered from orthology : A6NFX1 / major facilitator superfamily domain containing 2B
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 4862440
Gene end: 4874359
  
Corresponding Affymetrix probe sets: 10399314 (MoGene1.0st)   1442000_at (Mouse Genome 430 2.0 Array)   1457933_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045315
Ensembl peptide - ENSMUSP00000117057
Ensembl peptide - ENSMUSP00000114977
Ensembl peptide - ENSMUSP00000082945
NCBI entrez gene - 432628     See in Manteia.
MGI - MGI:3583946
RefSeq - XM_006515146
RefSeq - NM_001033488
RefSeq - XM_006515144
RefSeq Peptide - NP_001028660
swissprot - D6RDD7
swissprot - Q3T9M1
swissprot - B8JK42
swissprot - B8JK43
Ensembl - ENSMUSG00000037336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mfsd2bENSDARG00000030263Danio rerio
 MFSD2BENSGALG00000016498Gallus gallus
 A6NFX1ENSG00000205639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mfsd2a / Q9DA75 / Sodium-dependent lysophosphatidylcholine symporter 1 / Q8NA29* / major facilitator superfamily domain containing 2A*ENSMUSG0000002865542


Protein motifs (from Interpro)
Interpro ID Name
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0046624 sphingolipid transporter activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0000226 abnormal mean corpuscular volume "deviation from the norm for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

 MP:0010074 stomatocytosis "deformation of red blood cells to a cup-like shape, with swelling and with an elongated area of central pallor, instead of the normal biconcave shape" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

 MP:0010163 hemolysis "destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

 MP:0012232 abnormal ceramide level 
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Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

 MP:0020116 increased sphingosine level "increased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid" [GOC:NV, http://en.wikipedia.org/wiki/Sphingosine]
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Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

 MP:0020117 decreased sphingosine level "decreased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid" [GOC:NV, http://en.wikipedia.org/wiki/Sphingosine]
Show

Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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