ENSMUSG00000037406


Mus musculus

Features
Gene ID: ENSMUSG00000037406
  
Biological name :Htra4
  
Synonyms : A2RT60 / Htra4 / Serine protease HTRA4
  
Possible biological names infered from orthology : HtrA serine peptidase 4 / P83105
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 25024929
Gene end: 25038962
  
Corresponding Affymetrix probe sets: 10577782 (MoGene1.0st)   1437273_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081044
NCBI entrez gene - 330723     See in Manteia.
MGI - MGI:3036260
RefSeq - NM_001081187
RefSeq Peptide - NP_001074656
swissprot - A2RT60
Ensembl - ENSMUSG00000037406
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htra4ENSDARG00000005943Danio rerio
 HTRA4ENSG00000169495Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htra1 / Q9R118 / Serine protease HTRA1 / Q92743* / HtrA serine peptidase 1*ENSMUSG0000000620555
Htra3 / Q9D236 / Serine protease HTRA3 / P83110* / HtrA serine peptidase 3*ENSMUSG0000002909649
Htra2 / Q9JIY5 / Serine protease HTRA2, mitochondrial / O43464* / HtrA serine peptidase 2*ENSMUSG0000006832939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR001478  PDZ domain
 IPR001940  Peptidase S1C
 IPR002350  Kazal domain
 IPR009003  Peptidase S1, PA clan
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036034  PDZ superfamily
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0006508 proteolysis ISO
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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