ENSMUSG00000037446


Mus musculus

Features
Gene ID: ENSMUSG00000037446
  
Biological name :Tulp1
  
Synonyms : Q9Z273 / tubby like protein 1 / Tulp1
  
Possible biological names infered from orthology : O00294
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 28351515
Gene end: 28365182
  
Corresponding Affymetrix probe sets: 10449435 (MoGene1.0st)   1451582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110442
Ensembl peptide - ENSMUSP00000116844
Ensembl peptide - ENSMUSP00000121444
Ensembl peptide - ENSMUSP00000049070
Ensembl peptide - ENSMUSP00000116588
NCBI entrez gene - 22157     See in Manteia.
MGI - MGI:109571
RefSeq - XM_017317394
RefSeq - NM_021478
RefSeq Peptide - NP_067453
swissprot - F6R7T6
swissprot - B8JJC6
swissprot - Q8K0Y6
swissprot - Q9Z273
swissprot - F7BGL3
Ensembl - ENSMUSG00000037446
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tulp1aENSDARG00000075295Danio rerio
 tulp1bENSDARG00000078210Danio rerio
 TULP1ENSGALG00000031301Gallus gallus
 TULP1ENSG00000112041Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tub / P50586 / tubby bipartite transcription factor / P50607*ENSMUSG0000003102843
Tulp3 / O88413 / tubby-like protein 3 / O75386*ENSMUSG0000000152139
Tulp2 / P46686 / tubby-like protein 2 / O00295*ENSMUSG0000002346735
Tulp4 / Q9JIL5 / tubby like protein 4 / Q9NRJ4*ENSMUSG0000003437722
Wdr35 / Q8BND3 / WD repeat domain 35 / Q9P2L0*ENSMUSG0000006664317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000007  Tubby, C-terminal
 IPR018066  Tubby, C-terminal, conserved site
 IPR025659  Tubby-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001895 retina homeostasis IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006910 phagocytosis, recognition IMP
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050908 detection of light stimulus involved in visual perception IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0097500 receptor localization to non-motile cilium IBA
 biological_processGO:1903546 protein localization to photoreceptor outer segment IMP
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043679 axon terminus IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008583 absent photoreceptor inner segment "absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Tulp3tm1Jng/Tulp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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