ENSMUSG00000037499


Mus musculus

Features
Gene ID: ENSMUSG00000037499
  
Biological name :Nenf
  
Synonyms : Nenf / Neudesin / Q9CQ45
  
Possible biological names infered from orthology : neudesin neurotrophic factor / Q9UMX5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 191306789
Gene end: 191318194
  
Corresponding Affymetrix probe sets: 10361098 (MoGene1.0st)   1417879_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046311
NCBI entrez gene - 66208     See in Manteia.
MGI - MGI:1913458
RefSeq - NM_025424
RefSeq Peptide - NP_079700
swissprot - Q9CQ45
Ensembl - ENSMUSG00000037499
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nenfENSDARG00000040192Danio rerio
 NENFENSGALG00000009821Gallus gallus
 NENFENSG00000117691Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyb5d2 / Q5SSH8 / Neuferricin / Q8WUJ1* / cytochrome b5 domain containing 2*ENSMUSG0000005777831


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032099 negative regulation of appetite IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IBA
 molecular_functionGO:0008083 growth factor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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