ENSMUSG00000037652


Mus musculus

Features
Gene ID: ENSMUSG00000037652
  
Biological name :Phc3
  
Synonyms : Phc3 / Polyhomeotic-like protein 3 / Q8CHP6
  
Possible biological names infered from orthology : polyhomeotic homolog 3 / Q8NDX5
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A3
Gene start: 30899371
Gene end: 30969415
  
Corresponding Affymetrix probe sets: 10497646 (MoGene1.0st)   10497648 (MoGene1.0st)   1443651_at (Mouse Genome 430 2.0 Array)   1455312_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114916
Ensembl peptide - ENSMUSP00000103890
Ensembl peptide - ENSMUSP00000117614
Ensembl peptide - ENSMUSP00000136820
Ensembl peptide - ENSMUSP00000130142
Ensembl peptide - ENSMUSP00000037862
Ensembl peptide - ENSMUSP00000065617
Ensembl peptide - ENSMUSP00000096767
NCBI entrez gene - 241915     See in Manteia.
MGI - MGI:2181434
RefSeq - XM_017319572
RefSeq - NM_001165954
RefSeq - NM_001165955
RefSeq - NM_001165956
RefSeq - NM_153421
RefSeq - XM_006535467
RefSeq - XM_006535468
RefSeq - XM_006535469
RefSeq - XM_006535470
RefSeq - XM_006535471
RefSeq - XM_011249677
RefSeq Peptide - NP_001159427
RefSeq Peptide - NP_001159428
RefSeq Peptide - NP_700470
RefSeq Peptide - NP_001159426
swissprot - B7ZNA5
swissprot - E9QPT4
swissprot - Q8CHP6
swissprot - D6REI6
swissprot - F8WIN6
swissprot - D3YY34
Ensembl - ENSMUSG00000037652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000009372Gallus gallus
 PHC3ENSG00000173889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phc2 / Q9QWH1 / Polyhomeotic-like protein 2 / Q8IXK0* / polyhomeotic homolog 2*ENSMUSG0000002879636
Phc1 / Mus musculus polyhomeotic 1 (Phc1), transcript variant 5, mRNA. / P78364* / polyhomeotic homolog 1*ENSMUSG0000004066932
Q1RNF8 / Samd11 / Sterile alpha motif domain-containing protein 11 / Q96NU1* / sterile alpha motif domain containing 11*ENSMUSG000000963519
Samd7 / Q8C8Y5 / Sterile alpha motif domain-containing protein 7 / Q7Z3H4* / sterile alpha motif domain containing 7*ENSMUSG000000518608


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR012313  Zinc finger, FCS-type
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0031519 PcG protein complex ISO
 cellular_componentGO:0035102 PRC1 complex ISS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018537 Pcgf2 / P23798 / Polycomb group RING finger protein 2 / P35227* / polycomb group ring finger 2*  / complex
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / complex
 ENSMUSG00000026739 Bmi1 / P25916 / Polycomb complex protein BMI-1 / P35226* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / BMI1 proto-oncogene, polycomb ring finger*  / complex
 ENSMUSG00000072872 Rybp / Q8CCI5 / RING1 and YY1-binding protein / Q8N488*  / complex






 

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