ENSMUSG00000037999


Mus musculus

Features
Gene ID: ENSMUSG00000037999
  
Biological name :Arap2
  
Synonyms : Arap2 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  
Possible biological names infered from orthology : Q8WZ64
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.1
Gene start: 62602445
Gene end: 62766159
  
Corresponding Affymetrix probe sets: 10530100 (MoGene1.0st)   1436895_at (Mouse Genome 430 2.0 Array)   1452291_at (Mouse Genome 430 2.0 Array)   1456337_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075924
Ensembl peptide - ENSMUSP00000124743
NCBI entrez gene - 212285     See in Manteia.
MGI - MGI:2684416
RefSeq - XM_006503828
RefSeq - XM_011240712
RefSeq - NM_178407
RefSeq - XM_006503829
RefSeq Peptide - NP_848494
swissprot - E9QP44
swissprot - E0CXD0
Ensembl - ENSMUSG00000037999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR387919.1ENSDARG00000100518Danio rerio
 ARAP2ENSGALG00000041373Gallus gallus
 ARAP2ENSG00000047365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arap1 / Q4LDD4 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 / Q96P48* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1*ENSMUSG0000003281231
Arap3 / Q8R5G7 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 / Q8WWN8* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3*ENSMUSG0000002445130
Arhgap5 / Rho GTPase activating protein 5 / Q13017*ENSMUSG0000003513311
Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*ENSMUSG0000005823011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001164  Arf GTPase activating protein
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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