ENSMUSG00000038028


Mus musculus

Features
Gene ID: ENSMUSG00000038028
  
Biological name :Tigar
  
Synonyms : Q8BZA9 / Tigar / Trp53 induced glycolysis repulatory phosphatase
  
Possible biological names infered from orthology : Q9NQ88 / TP53 induced glycolysis regulatory phosphatase
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 127085116
Gene end: 127109557
  
Corresponding Affymetrix probe sets: 10548097 (MoGene1.0st)   1435929_at (Mouse Genome 430 2.0 Array)   1439859_at (Mouse Genome 430 2.0 Array)   1447934_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048643
Ensembl peptide - ENSMUSP00000144435
NCBI entrez gene - 319801     See in Manteia.
MGI - MGI:2442752
RefSeq - NM_177003
RefSeq - XM_006506254
RefSeq Peptide - NP_795977
swissprot - B2RWB7
swissprot - A0A0J9YV11
swissprot - Q8BZA9
Ensembl - ENSMUSG00000038028
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q29RA5ENSDARG00000051749Danio rerio
 tigarbENSDARG00000045858Danio rerio
 TIGARENSGALG00000026776Gallus gallus
 TIGARENSG00000078237Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IDA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process ISO
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009410 response to xenobiotic stimulus IMP
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030388 fructose 1,6-bisphosphate metabolic process ISO
 biological_processGO:0033673 negative regulation of kinase activity IC
 biological_processGO:0043069 negative regulation of programmed cell death ISS
 biological_processGO:0043456 regulation of pentose-phosphate shunt ISO
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0045820 negative regulation of glycolytic process IDA
 biological_processGO:0060576 intestinal epithelial cell development IMP
 biological_processGO:0071279 cellular response to cobalt ion ISO
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:1901215 negative regulation of neuron death IDA
 biological_processGO:1901525 negative regulation of mitophagy IMP
 biological_processGO:1902153 regulation of response to DNA damage checkpoint signaling ISO
 biological_processGO:1903301 positive regulation of hexokinase activity ISO
 biological_processGO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004083 bisphosphoglycerate 2-phosphatase activity ISO
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008402 increased cellular sensitivity to alkylating agents "greater incidence of cell death following exposure to agents that cause DNA damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tigartm1.1Khv/Tigartm1.1Khv,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

 MP:0008800 increased small intestinal crypt cell apoptosis "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu,Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

 MP:0010156 abnormal small intestinal crypt cell physiology "altered function of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
Show

Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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