ENSMUSG00000038987


Mus musculus
spermCfap157cellbindingmalemotilityheadspermatogenesisaxonemeassemblydifferentiationcytoplasmcytosolcytoskeletonplasmamembraneciliumciliarybasalbodyprojectionintracellularmembrane-boundedorganelleproteinmicrotubulecontentinfertilitycaudadecreasedgerm

Features
Gene ID: ENSMUSG00000038987
  
Biological name :Cfap157
  
Synonyms : Cfap157 / Cilia- and flagella-associated protein 157 / Q0VFX2
  
Possible biological names infered from orthology : Q5JU67
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32777381
Gene end: 32784428
  
Corresponding Affymetrix probe sets: 10481700 (MoGene1.0st)   1429845_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099877
NCBI entrez gene - 227736     See in Manteia.
MGI - MGI:2447809
RefSeq - NM_025619
RefSeq Peptide - NP_079895
swissprot - Q0VFX2
Ensembl - ENSMUSG00000038987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2BDR7ENSDARG00000099042Danio rerio
 Q5JU67ENSG00000160401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
multicellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular organism reproductioncellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmicrotubule-based processmulticellular orgmulticellular organism reproductioncellular componencellular component organizationcellular componencellular component biogenesislocalization of clocalization of cellmovement of cell movement of cell or subcellular componentanatomical structanatomical structure developmentcellular developmcellular developmental processmicrotubule-basedmicrotubule-based process
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
cellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypereproductive system phenotypecellular phenotypecellular phenotypereproductive system phenotypereproductive system phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0009234 absent sperm head "absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0009282 reduced hyperactivated sperm motility "loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,X/Yaa
Genetic Background: BXSB.129S2(B6)-Cd8atm1Mak/4Dcr

Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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