ENSMUSG00000039103


Mus musculus

Features
Gene ID: ENSMUSG00000039103
  
Biological name :Nexn
  
Synonyms : Nexilin / Nexn / Q7TPW1
  
Possible biological names infered from orthology : nexilin F-actin binding protein / Q0ZGT2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H3
Gene start: 152236982
Gene end: 152266350
  
Corresponding Affymetrix probe sets: 10502830 (MoGene1.0st)   1435649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037120
Ensembl peptide - ENSMUSP00000143573
Ensembl peptide - ENSMUSP00000143436
Ensembl peptide - ENSMUSP00000143294
Ensembl peptide - ENSMUSP00000143180
Ensembl peptide - ENSMUSP00000143133
Ensembl peptide - ENSMUSP00000142936
Ensembl peptide - ENSMUSP00000142574
Ensembl peptide - ENSMUSP00000142573
Ensembl peptide - ENSMUSP00000142569
Ensembl peptide - ENSMUSP00000142559
NCBI entrez gene - 68810     See in Manteia.
MGI - MGI:1916060
RefSeq - XM_006501990
RefSeq - XM_011240215
RefSeq - XM_011240214
RefSeq - XM_006502002
RefSeq - XM_006502000
RefSeq - XM_006501998
RefSeq - XM_006501996
RefSeq - XM_006501993
RefSeq - XM_006501992
RefSeq - NM_199465
RefSeq - XM_006501991
RefSeq - XM_011240216
RefSeq Peptide - NP_955759
RefSeq Peptide - NP_001344135
swissprot - Q7TPW1
swissprot - A0A0G2JGI1
swissprot - A0A0G2JDY6
swissprot - A0A0G2JDZ3
swissprot - A0A0G2JDZ7
swissprot - A0A0G2JDZ8
swissprot - A0A0G2JEX1
swissprot - A0A0G2JFD8
swissprot - A0A0G2JFI0
swissprot - A0A0G2JFT2
swissprot - A0A0G2JG59
Ensembl - ENSMUSG00000039103
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nexnENSDARG00000057317Danio rerio
 NEXNENSGALG00000008945Gallus gallus
 NEXNENSG00000162614Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0048739 cardiac muscle fiber development IBA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0030018 Z disc IBA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0008307 structural constituent of muscle IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

Allelic Composition: Nexntm1.1Zhh/Nexn+
Genetic Background: involves: C57BL/6NTac

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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