ENSMUSG00000039315


Mus musculus

Features
Gene ID: ENSMUSG00000039315
  
Biological name :Clnk
  
Synonyms : Clnk / Cytokine-dependent hematopoietic cell linker / Q9QZE2
  
Possible biological names infered from orthology : Q7Z7G1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 38706462
Gene end: 38876812
  
Corresponding Affymetrix probe sets: 10529711 (MoGene1.0st)   1420463_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128473
Ensembl peptide - ENSMUSP00000132779
NCBI entrez gene - 27278     See in Manteia.
MGI - MGI:1351468
RefSeq - XM_011240735
RefSeq - NM_013748
RefSeq - XM_006503974
RefSeq - XM_011240734
RefSeq Peptide - NP_038776
swissprot - E9PXZ8
swissprot - Q9QZE2
Ensembl - ENSMUSG00000039315
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01088229.1ENSDARG00000091321Danio rerio
 CLNKENSG00000109684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*ENSMUSG0000000269921
Blnk / Q9QUN3 / B-cell linker protein / Q8WV28* / B cell linker*ENSMUSG0000006113220
Sh2d6 / Q7Z4S9* / SH2 domain containing 6*ENSMUSG0000005263114


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003080 competent NK cell cytolysis "ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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