ENSMUSG00000039601


Mus musculus

Features
Gene ID: ENSMUSG00000039601
  
Biological name :Rcan2
  
Synonyms : Q9JHG2 / Rcan2 / regulator of calcineurin 2
  
Possible biological names infered from orthology : Q14206
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 43801351
Gene end: 44039516
  
Corresponding Affymetrix probe sets: 10445325 (MoGene1.0st)   1421425_a_at (Mouse Genome 430 2.0 Array)   1450243_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039473
Ensembl peptide - ENSMUSP00000048013
Ensembl peptide - ENSMUSP00000137211
Ensembl peptide - ENSMUSP00000154835
Ensembl peptide - ENSMUSP00000155082
Ensembl peptide - ENSMUSP00000155543
Ensembl peptide - ENSMUSP00000155555
NCBI entrez gene - 53901     See in Manteia.
MGI - MGI:1858219
RefSeq - XM_006524622
RefSeq - NM_001286653
RefSeq - NM_001286654
RefSeq - NM_001357742
RefSeq - NM_030598
RefSeq - NM_207649
RefSeq Peptide - NP_001273583
RefSeq Peptide - NP_001344671
RefSeq Peptide - NP_085101
RefSeq Peptide - NP_997532
RefSeq Peptide - NP_001273582
swissprot - Q8VIP4
swissprot - Q9JHG2
swissprot - Q543P2
Ensembl - ENSMUSG00000039601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rcan2ENSDARG00000021869Danio rerio
 RCAN2ENSGALG00000016709Gallus gallus
 RCAN2ENSG00000172348Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rcan3 / Q9JKK0 / Calcipressin-3 / Q9UKA8* / RCAN family member 3*ENSMUSG0000005971359
Rcan1 / Q9JHG6 / regulator of calcineurin 1 / P53805*ENSMUSG0000002295151


Protein motifs (from Interpro)
Interpro ID Name
 IPR006931  Calcipressin
 IPR034919  Calcipressin-2, RNA recognition motif
 IPR034921  Calcipressin-2
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IGI
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007614 short-term memory IGI
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0031987 locomotion involved in locomotory behavior IGI
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0070884 regulation of calcineurin-NFAT signaling cascade IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0009305 decreased retroperitoneal fat pad weight 
Show

Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
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Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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