ENSMUSG00000039878


Mus musculus

Features
Gene ID: ENSMUSG00000039878
  
Biological name :Slc39a5
  
Synonyms : Q9D856 / Slc39a5 / Zinc transporter ZIP5
  
Possible biological names infered from orthology : Q6ZMH5 / solute carrier family 39 member 5
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128395931
Gene end: 128401229
  
Corresponding Affymetrix probe sets: 10373374 (MoGene1.0st)   1429523_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151742
Ensembl peptide - ENSMUSP00000037753
Ensembl peptide - ENSMUSP00000131736
Ensembl peptide - ENSMUSP00000151727
NCBI entrez gene - 72002     See in Manteia.
MGI - MGI:1919336
RefSeq - XM_006514173
RefSeq - NM_001136237
RefSeq - NM_028051
RefSeq - NM_028092
RefSeq - XM_006514172
RefSeq Peptide - NP_001129709
RefSeq Peptide - NP_082327
RefSeq Peptide - NP_082368
swissprot - A0A1W2P7R0
swissprot - Q9D856
swissprot - A0A1W2P7Q2
Ensembl - ENSMUSG00000039878
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc39a5ENSDARG00000079525Danio rerio
 ENSGALG00000046197Gallus gallus
 Q6ZMH5ENSG00000139540Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6P5F6 / Slc39a10 / Zinc transporter ZIP10 / Q9ULF5* / solute carrier family 39 member 10*ENSMUSG0000002598634
Q8C145 / Slc39a6 / Zinc transporter ZIP6 / Q13433* / solute carrier family 39 member 6*ENSMUSG0000002427031
Q78IQ7 / Slc39a4 / solute carrier family 39 (zinc transporter), member 4 / Q6P5W5* / solute carrier family 39 member 4*ENSMUSG0000006335428
Q5FWH7 / Slc39a12 / Zinc transporter ZIP12 / Q504Y0* / solute carrier family 39 member 12*ENSMUSG0000003694924
Q91W10 / Slc39a8 / Zinc transporter ZIP8 / Q9C0K1* / solute carrier family 39 member 8*ENSMUSG0000005389722
Q75N73 / Slc39a14 / solute carrier family 39 (zinc transporter), member 14 / Q15043* / solute carrier family 39 member 14*ENSMUSG0000002209421
Q31125 / Slc39a7 / solute carrier family 39 (zinc transporter), member 7 / Q92504* / solute carrier family 39 member 7*ENSMUSG0000002432720
Q8BZH0 / Slc39a13 / solute carrier family 39 (metal ion transporter), member 13 / Q96H72* / solute carrier family 39 member 13*ENSMUSG0000000210516


Protein motifs (from Interpro)
Interpro ID Name
 IPR003689  Zinc/iron permease


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development ISS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0006882 cellular zinc ion homeostasis TAS
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0034224 cellular response to zinc ion starvation IDA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071578 zinc ion import across plasma membrane IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity TAS
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0004761 susceptibility to induced pancreatitis "more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alg10bnse5/Alg10bnse5
Genetic Background: 129S6.B6-Alg10bnse5

Allelic Composition: Slc39a5tm1Gka/Slc39a5tm1Gka,Tg(Cela1-cre/ERT)1Lgdn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008743 decreased liver iron level "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc39a5tm1Gka/Slc39a5tm1Gka,Tg(Cela1-cre/ERT)1Lgdn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009150 pancreatic acinar cell atrophy "wasting of the pancreatic acinar cells due to injury or disease, resulting in reduced size or number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alg10bnse5/Alg10bnse5
Genetic Background: 129S6.B6-Alg10bnse5

Allelic Composition: Slc39a5tm1Gka/Slc39a5tm1Gka,Tg(Cela1-cre/ERT)1Lgdn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009615 abnormal zinc homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of zinc that normally is a cofactor in many proteins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alg10bnse5/Alg10bnse5
Genetic Background: 129S6.B6-Alg10bnse5

Allelic Composition: Slc39a5tm1Gka/Slc39a5tm1Gka,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Slc39a5tm1Gka/Slc39a5tm1Gka,Tg(Cela1-cre/ERT)1Lgdn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011924 abnormal liver zinc level "anomaly in the amount of zinc present in the liver tissue" [MPD:Molly]
Show

Allelic Composition: Alg10bnse5/Alg10bnse5
Genetic Background: 129S6.B6-Alg10bnse5

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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