ENSMUSG00000040013


Mus musculus

Features
Gene ID: ENSMUSG00000040013
  
Biological name :Fkbp6
  
Synonyms : Fkbp6 / Inactive peptidyl-prolyl cis-trans isomerase FKBP6 / Q91XW8
  
Possible biological names infered from orthology : FK506 binding protein 6 / O75344
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 135291704
Gene end: 135350044
  
Corresponding Affymetrix probe sets: 10534428 (MoGene1.0st)   1425101_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043193
Ensembl peptide - ENSMUSP00000144381
Ensembl peptide - ENSMUSP00000144460
Ensembl peptide - ENSMUSP00000144471
NCBI entrez gene - 94244     See in Manteia.
MGI - MGI:2137612
RefSeq - XM_017321190
RefSeq - NM_001277891
RefSeq - NM_001277892
RefSeq - NM_001277893
RefSeq - NM_033571
RefSeq - XM_011240913
RefSeq - XM_011240915
RefSeq - XM_017321189
RefSeq Peptide - NP_001264820
RefSeq Peptide - NP_001264821
RefSeq Peptide - NP_001264822
RefSeq Peptide - NP_291049
swissprot - Q91XW8
Ensembl - ENSMUSG00000040013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbp6ENSDARG00000030133Danio rerio
 FKBP6ENSGALG00000029211Gallus gallus
 FKBP6ENSG00000077800Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fkbp8 / O35465 / Peptidyl-prolyl cis-trans isomerase FKBP8 / Q14318* / FK506 binding protein 8*ENSMUSG0000001942824


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006457 protein folding IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0018208 peptidyl-proline modification IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0045070 positive regulation of viral genome replication ISO
 biological_processGO:0051321 meiotic cell cycle IMP
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005528 FK506 binding IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Kittm2Bsm/Kit+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Kittm2Bsm/Kit+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kittm2Bsm/Kit+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kittm2Bsm/Kit+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kittm2Bsm/Kit+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex






 

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