ENSMUSG00000040136


Mus musculus

Features
Gene ID: ENSMUSG00000040136
  
Biological name :Abcc8
  
Synonyms : Abcc8 / ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 46104523
Gene end: 46180033
  
Corresponding Affymetrix probe sets: 10563487 (MoGene1.0st)   1455765_a_at (Mouse Genome 430 2.0 Array)   1457066_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033123
Ensembl peptide - ENSMUSP00000148198
Ensembl peptide - ENSMUSP00000148169
Ensembl peptide - ENSMUSP00000147925
Ensembl peptide - ENSMUSP00000147479
Ensembl peptide - ENSMUSP00000147431
NCBI entrez gene - 20927     See in Manteia.
MGI - MGI:1352629
RefSeq - XM_006540750
RefSeq - NM_001357538
RefSeq - NM_011510
RefSeq - XM_006540749
RefSeq Peptide - NP_001344467
RefSeq Peptide - NP_035640
swissprot - B2RUS7
swissprot - A0A1B0GT25
swissprot - A0A1B0GSG2
swissprot - A0A1B0GR95
swissprot - A0A1B0GRD7
swissprot - A0A1B0GT49
Ensembl - ENSMUSG00000040136
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000388  Sulphonylurea receptor
 IPR000844  ATP-binding cassette subfamily C member 8
 IPR001475  ATP-binding cassette subfamily C member 9
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043268 positive regulation of potassium ion transport IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0061045 negative regulation of wound healing IEA
 biological_processGO:0061855 negative regulation of neuroblast migration IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1900721 positive regulation of uterine smooth muscle relaxation IEA
 biological_processGO:1903818 positive regulation of voltage-gated potassium channel activity IEA
 biological_processGO:1905075 positive regulation of occluding junction disassembly IEA
 biological_processGO:1905604 negative regulation of maintenance of permeability of blood-brain barrier IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IBA
 cellular_componentGO:0008282 inward rectifying potassium channel ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005267 potassium channel activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008281 sulfonylurea receptor activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA
 molecular_functionGO:0044325 ion channel binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Unc5crcmTg(Ucp)1.23Kz/Unc5crcmTg(Ucp)1.23Kz
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Abcc8tm1.1Mgn/Abcc8tm1.1Mgn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc8tm1.1Mgn/Abcc8tm1.1Mgn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry,Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry,Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry
Genetic Background: involves: 129X1/SvJ

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hprttm363a(hs1218-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm363a(hs1218-icre/ERT2)Ems

Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Unc5crcmTg(Ucp)1.23Kz/Unc5crcmTg(Ucp)1.23Kz
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Abcc8tm1.1Mgn/Abcc8tm1.1Mgn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry,Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sstr5tm1Fcb/Sstr5tm1Fcb
Genetic Background: involves: 129

Allelic Composition: Abcc8tm1Jbry/Abcc8tm1Jbry
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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