ENSMUSG00000040220


Mus musculus

Features
Gene ID: ENSMUSG00000040220
  
Biological name :Gas8
  
Synonyms : Gas8 / Growth arrest-specific protein 8 / Q60779
  
Possible biological names infered from orthology : growth arrest specific 8 / O95995
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 123518834
Gene end: 123536650
  
Corresponding Affymetrix probe sets: 10576373 (MoGene1.0st)   1418361_at (Mouse Genome 430 2.0 Array)   1440788_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090730
Ensembl peptide - ENSMUSP00000148576
NCBI entrez gene - 104346     See in Manteia.
MGI - MGI:1202386
RefSeq - XM_011248259
RefSeq - NM_018855
RefSeq - XM_006530551
RefSeq Peptide - NP_061343
swissprot - Q49MD7
swissprot - Q60779
swissprot - A0A1D5RM05
Ensembl - ENSMUSG00000040220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gas8ENSDARG00000101431Danio rerio
 GAS8ENSGALG00000000540Gallus gallus
 GAS8ENSG00000141013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR025593  Growth arrest-specific protein 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0030317 flagellated sperm motility IEP
 biological_processGO:0034613 cellular protein localization IDA
 biological_processGO:0035082 axoneme assembly IMP
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0060294 cilium movement involved in cell motility IEA
 biological_processGO:1904526 regulation of microtubule binding IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IBA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097729 9+2 motile cilium IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0017137 Rab GTPase binding IDA


Pathways (from Reactome)
Pathway description
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Disp1icb/Disp1icb,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Disp1icb/Disp1icb,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1icb,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1icb,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0011069 abnormal brain ependyma motile cilium physiology "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1icb,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Disp1icb/Disp1icb,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0011253 situs inversus with levocardia "situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Disp1icb/Disp1icb,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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