ENSMUSG00000040229


Mus musculus

Features
Gene ID: ENSMUSG00000040229
  
Biological name :Gpr34
  
Synonyms : Gpr34 / Probable G-protein coupled receptor 34 / Q9R1K6
  
Possible biological names infered from orthology : G protein-coupled receptor 34 / Q9UPC5
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 13632089
Gene end: 13640858
  
Corresponding Affymetrix probe sets: 10598750 (MoGene1.0st)   1422542_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042715
Ensembl peptide - ENSMUSP00000094236
NCBI entrez gene - 23890     See in Manteia.
MGI - MGI:1346334
RefSeq - XM_006527625
RefSeq - NM_011823
RefSeq - XM_006527624
RefSeq Peptide - NP_035953
swissprot - Q9R1K6
swissprot - Q3YL73
Ensembl - ENSMUSG00000040229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr34bENSDARG00000002959Danio rerio
 GPR34ENSGALG00000016227Gallus gallus
 GPR34ENSG00000171659Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2ry14 / Q9ESG6 / purinergic receptor P2Y, G-protein coupled, 14 / Q15391* / purinergic receptor P2Y14*ENSMUSG0000003638125
P2ry12 / Q9CPV9 / purinergic receptor P2Y, G-protein coupled 12 / Q9H244* / purinergic receptor P2Y12*ENSMUSG0000003635324
Gpr87 / Q99MT7 / G-protein coupled receptor 87 / Q9BY21*ENSMUSG0000005143124
P2ry13 / Q9D8I2 / P2Y purinoceptor 13 / Q9BPV8* / purinergic receptor P2Y13*ENSMUSG0000003636222
Gpr171 / Q8BG55 / G protein-coupled receptor 171 / O14626*ENSMUSG0000005007522
Gpr82 / Q8BZR0 / Probable G-protein coupled receptor 82 / Q96P67* / G protein-coupled receptor 82*ENSMUSG0000004767819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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