ENSMUSG00000040435


Mus musculus

Features
Gene ID: ENSMUSG00000040435
  
Biological name :Ppp1r15a
  
Synonyms : P17564 / Ppp1r15a / protein phosphatase 1, regulatory (inhibitor) subunit 15A
  
Possible biological names infered from orthology : O75807 / protein phosphatase 1 regulatory subunit 15A
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45522916
Gene end: 45526268
  
Corresponding Affymetrix probe sets: 10563338 (MoGene1.0st)   1448325_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049488
Ensembl peptide - ENSMUSP00000147703
Ensembl peptide - ENSMUSP00000128497
NCBI entrez gene - 17872     See in Manteia.
MGI - MGI:1927072
RefSeq - NM_008654
RefSeq Peptide - NP_032680
swissprot - B2RRL7
swissprot - A0A1B0GRX4
swissprot - P17564
Ensembl - ENSMUSG00000040435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r15aENSDARG00000069135Danio rerio
 O75807ENSG00000087074Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019523  Protein phosphatase 1, regulatory subunit 15A/B, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0035308 negative regulation of protein dephosphorylation ISO
 biological_processGO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation ISO
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IDA
 biological_processGO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
 biological_processGO:0070262 peptidyl-serine dephosphorylation IDA
 biological_processGO:0070972 protein localization to endoplasmic reticulum ISO
 biological_processGO:1902310 positive regulation of peptidyl-serine dephosphorylation IDA
 biological_processGO:1903573 negative regulation of response to endoplasmic reticulum stress IDA
 biological_processGO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
 biological_processGO:1903917 positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation ISO
 biological_processGO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
 cellular_componentGO:0000164 protein phosphatase type 1 complex ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0008157 protein phosphatase 1 binding ISO
 molecular_functionGO:0019888 protein phosphatase regulator activity IDA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Robo1tm1.1Ljr/Robo1tm1.1Ljr
Genetic Background: B6.129-Robo1tm1.1Ljr

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

Allelic Composition: Ppp1r15atm1Kii/Ppp1r15atm1Kii
Genetic Background: involves: 129P2/OlaHsd

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0010175 leptocytosis "the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull s-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0010177 acanthocytosis "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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