ENSMUSG00000040479


Mus musculus

Features
Gene ID: ENSMUSG00000040479
  
Biological name :Dgkz
  
Synonyms : Dgkz / Diacylglycerol kinase zeta / Q80UP3
  
Possible biological names infered from orthology : Q13574
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E1
Gene start: 91932824
Gene end: 91975864
  
Corresponding Affymetrix probe sets: 10485081 (MoGene1.0st)   10485115 (MoGene1.0st)   1426738_at (Mouse Genome 430 2.0 Array)   1452169_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106934
Ensembl peptide - ENSMUSP00000028667
Ensembl peptide - ENSMUSP00000106937
Ensembl peptide - ENSMUSP00000119615
Ensembl peptide - ENSMUSP00000118684
Ensembl peptide - ENSMUSP00000114740
NCBI entrez gene - 104418     See in Manteia.
MGI - MGI:1278339
RefSeq - XM_017314878
RefSeq - XM_006498539
RefSeq - XM_006498540
RefSeq - XM_006498541
RefSeq - XM_006498542
RefSeq - XM_006498543
RefSeq - XM_011239240
RefSeq - XM_017314867
RefSeq - XM_017314875
RefSeq - NM_001166597
RefSeq - NM_138306
RefSeq - XM_006498537
RefSeq - XM_006498538
RefSeq Peptide - NP_001160069
RefSeq Peptide - NP_612179
swissprot - D6RDR3
swissprot - A2AHK0
swissprot - D6RIP2
swissprot - A2AHJ7
swissprot - Q80UP3
swissprot - D6RHK9
Ensembl - ENSMUSG00000040479
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkzaENSDARG00000014439Danio rerio
 dgkzbENSDARG00000076025Danio rerio
 DGKZENSGALG00000008380Gallus gallus
 DGKZENSG00000149091Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dgki / diacylglycerol kinase iota isoform 2 / O75912* / diacylglycerol kinase iota*ENSMUSG0000003866554
Dgkh / diacylglycerol kinase eta / Q86XP1*ENSMUSG0000003473120
Dgkd / diacylglycerol kinase delta / Q16760*ENSMUSG0000007073820
Dgkg / Q91WG7 / Diacylglycerol kinase gamma / P49619*ENSMUSG0000002286119
Dgkb / Q6NS52 / Diacylglycerol kinase beta / Q9Y6T7*ENSMUSG0000003609518
Dgkk / diacylglycerol kinase kappa / Q5KSL6*ENSMUSG0000006239318
Dgkq / Q6P5E8 / Diacylglycerol kinase theta / P52824*ENSMUSG0000000481517
Dgka / O88673 / Mus musculus diacylglycerol kinase, alpha (Dgka), transcript variant 2, mRNA. / P23743* / diacylglycerol kinase alpha*ENSMUSG0000002535717
Dgke / Q9R1C6 / Diacylglycerol kinase epsilon / P52429*ENSMUSG0000000027615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle ISO
 biological_processGO:0046339 diacylglycerol metabolic process IEA
 biological_processGO:0046486 glycerolipid metabolic process IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 biological_processGO:0046834 lipid phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030027 lamellipodium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001727 lipid kinase activity ISO
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005004 clonal anergy "unresponsiveness to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0008686 abnormal interleukin-2 secretion "anomaly in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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