ENSMUSG00000040552


Mus musculus

Features
Gene ID: ENSMUSG00000040552
  
Biological name :C3ar1
  
Synonyms : C3a anaphylatoxin chemotactic receptor / C3ar1 / O09047
  
Possible biological names infered from orthology : complement C3a receptor 1 / Q16581
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 122847138
Gene end: 122856161
  
Corresponding Affymetrix probe sets: 10547657 (MoGene1.0st)   1419482_at (Mouse Genome 430 2.0 Array)   1419483_at (Mouse Genome 430 2.0 Array)   1442082_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048092
NCBI entrez gene - 12267     See in Manteia.
MGI - MGI:1097680
RefSeq - NM_009779
RefSeq Peptide - NP_033909
swissprot - O09047
swissprot - Q5U7A4
Ensembl - ENSMUSG00000040552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU861476.1ENSDARG00000031749Danio rerio
 C3AR1ENSGALG00000013218Gallus gallus
 C3AR1ENSG00000171860Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cmklr1 / P97468 / Mus musculus chemokine-like receptor 1 (Cmklr1), transcript variant 1, mRNA. / Q99788* / chemerin chemokine-like receptor 1*ENSMUSG0000004219026
Fpr1 / P33766 / fMet-Leu-Phe receptor / P21462* / formyl peptide receptor 1*ENSMUSG0000004555125
Fpr2 / O88536 / Formyl peptide receptor 2 / P25090*ENSMUSG0000005227025
C5ar1 / P30993 / C5a anaphylatoxin chemotactic receptor 1 / P21730* / complement C5a receptor 1*ENSMUSG0000004913024
Fpr3 / O08790 / Formyl peptide receptor-related sequence 1 / FPR2* / P25090* / formyl peptide receptor 2*ENSMUSG0000007970024
Gpr1 / Q8K087 / G-protein coupled receptor 1 / P46091*ENSMUSG0000004685623
Q3SXG2 / Fpr-rs6 / Formyl peptide receptor-related sequence 6 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127523
Q71MR7 / Fpr-rs7 / Formyl peptide receptor-related sequence 7 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127623
Ptgdr2 / Q9Z2J6 / Prostaglandin D2 receptor 2 / Q9Y5Y4*ENSMUSG0000003411722
A4FUQ5 / Fpr-rs4 / Formyl peptide receptor-related sequence 4 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000004806222
O88537 / Fpr-rs3 / Formyl peptide receptor-related sequence 3 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000006070122
C5ar2 / complement component 5a receptor 2 / Q9P296*ENSMUSG0000007436122
Gpr33 / O88416 / Probable G-protein coupled receptor 33 / Q49SQ1* / G protein-coupled receptor 33 (gene/pseudogene)*ENSMUSG0000003514820
Gpr152 / Q8BXS7 / G protein-coupled receptor 152 / Q8TDT2*ENSMUSG0000004472418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR001644  C3a anaphylatoxin chemotactic receptor
 IPR002234  Anaphylatoxin chemotactic receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002430 complement receptor mediated signaling pathway IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IMP
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IEA
 molecular_functionGO:0004876 complement component C3a receptor activity IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events
Neutrophil degranulation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0003959 abnormal lean body mass "aberrant fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Frem1bat/Frem1+
Genetic Background: C57BL/6J-Frem1bat

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Frem1bat/Frem1+
Genetic Background: C57BL/6J-Frem1bat

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: C3ar1tm1Raw/C3ar1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / complex / reaction






 

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