MP:0001800 | abnormal humoral immune response | "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Tmc1baringo/Tmc1baringo Genetic Background: involves: C57BL/6
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MP:0001805 | decreased IgG | "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
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MP:0001807 | decreased IgA | "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
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MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0002023 | B cell derived lymphoma | "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0002024 | T cell derived lymphoma | "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0002026 | leukemia | "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0002144 | abnormal B lymphocyte development | "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc Genetic Background: involves: 129
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg Genetic Background: involves: 129S1/Sv
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MP:0002459 | abnormal B cell physiology | "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Itgb4tm1Son/Itgb4tm1Son Genetic Background: 129P2/OlaHsd-Itgb4tm1Son
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Ightm3Mnz/Igh+,Myctm37Mnz/Myc+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
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MP:0002460 | decreased circulating immunoglobulin concentration | "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tmc1baringo/Tmc1baringo Genetic Background: involves: C57BL/6
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MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
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MP:0004029 | spontaneous chromosome breakage | "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Itgb4tm1Son/Itgb4tm1Son Genetic Background: 129P2/OlaHsd-Itgb4tm1Son
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Ightm3Mnz/Igh+,Myctm37Mnz/Myc+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Tg(Cr2-cre)3Cgn/?,Xrcc4tm1Fwa/Xrcc4tm2Fwa Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA
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MP:0004030 | induced chromosome breakage | "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Ightm3Mnz/Igh+,Myctm37Mnz/Myc+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0004815 | abnormal somatic hypermutation frequency | "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Aicdatm1Hon/Aicda+ Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm3Mnz/Aicda+ Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm4Mnz/Aicda+ Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm1Hon/Aicdatm3Mnz Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm1Hon/Aicdatm4Mnz Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm3.1Mnz/Aicdatm3.1Mnz Genetic Background: involves: C57BL/6
Allelic Composition: Aicdatm4.1Mnz/Aicdatm4.1Mnz Genetic Background: involves: C57BL/6
Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon Genetic Background: C57BL/6-Aicdatm2.1Hon
Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Bcl6tm1.1Jwan/Bcl6tm1.1Jwan Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Aicdatm1.1Fwa/Aicdatm1.1Fwa Genetic Background: involves: 129S6/SvEvTac
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MP:0004816 | abnormal class switch recombination | "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Aicdatm1Hon/Aicda+ Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm3Mnz/Aicda+ Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm4Mnz/Aicda+ Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm1Hon/Aicdatm3Mnz Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm1Hon/Aicdatm4Mnz Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aicdatm3.1Mnz/Aicdatm3.1Mnz Genetic Background: involves: C57BL/6
Allelic Composition: Aicdatm4.1Mnz/Aicdatm4.1Mnz Genetic Background: involves: C57BL/6
Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ightm3Mnz/Ightm4.1Mnz,Trp53bp1tm1Jc/Trp53bp1tm1Jc Genetic Background: involves: 129 * C57BL/6 * CBA
Allelic Composition: Aicdatm1.1Fwa/Aicdatm1.1Fwa Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Aicdatm1Hon/Aicdatm1.1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj
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MP:0006283 | medulloblastoma | "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0008094 | absent memory B cells | "absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tmc1baringo/Tmc1baringo Genetic Background: involves: C57BL/6
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MP:0008098 | decreased plasma cell number | "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008100 | absent plasma cells | "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tmc1baringo/Tmc1baringo Genetic Background: involves: C57BL/6
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MP:0008177 | increased germinal center B cell number | "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon Genetic Background: C57BL/6-Aicdatm2.1Hon
Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon Genetic Background: involves: BALB/c * C57BL/6
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MP:0008178 | decreased germinal center B cell number | "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Tmc1baringo/Tmc1baringo Genetic Background: involves: C57BL/6
Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008192 | abnormal germinal center B cell physiology | "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Tmc1baringo/Tmc1baringo Genetic Background: involves: C57BL/6
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MP:0008495 | decreased IgG1 level | "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon Genetic Background: C57BL/6-Aicdatm2.1Hon
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MP:0008496 | decreased IgG2a level | "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
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MP:0008497 | decreased IgG2b level | "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
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MP:0008498 | decreased IgG3 level | "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
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MP:0008760 | abnormal immunoglobulin heavy chain V(D)J recombination | "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17tm1.2Rain/Adam17tm1.2Rain Genetic Background: C57BL/6-Adam17tm1.2Rain
Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ightm4.1Mnz/Igh+ Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Exo1tm1Wed/Exo1tm1Wed,Ightm4.1Mnz/Igh+,Trp53bp1tm1Jc/Trp53bp1tm1Jc Genetic Background: involves: 129 * C57BL/6 * CBA/JNCrlj * SJL
Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Exo1tm1Wed/Exo1tm1Wed,Ightm4.1Mnz/Igh+ Genetic Background: involves: C57BL/6 * CBA/JNCrlj * SJL
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MP:0008866 | chromosomal instability | "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840] |
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Allelic Composition: Raxey1/Raxey1 Genetic Background: involves: ZRDCT/Ch
Allelic Composition: Aicdatm1Hon/Aicdatm2Mnz Genetic Background: involves: C57BL/6 * CBA
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MP:0009317 | follicular lymphoma | "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0009704 | skin squamous cell carcinoma | "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon Genetic Background: C57BL/6-Aicdatm2.1Hon
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MP:0010296 | increased hemolymphoid system tumor incidence | "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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MP:0010377 | abnormal gut flora balance | "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon Genetic Background: C57BL/6-Aicdatm2.1Hon
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