ENSMUSG00000040629


Mus musculus

Features
Gene ID: ENSMUSG00000040629
  
Biological name :Mael
  
Synonyms : Mael / maelstrom spermatogenic transposon silencer / Q8BVN9
  
Possible biological names infered from orthology : Q96JY0
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.3
Gene start: 166201201
Gene end: 166238747
  
Corresponding Affymetrix probe sets: 10359801 (MoGene1.0st)   1436837_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141652
Ensembl peptide - ENSMUSP00000045828
NCBI entrez gene - 98558     See in Manteia.
MGI - MGI:2138453
RefSeq - NM_175296
RefSeq Peptide - NP_780505
swissprot - A0A0A6YWQ9
swissprot - Q8BVN9
Ensembl - ENSMUSG00000040629
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAELENSGALG00000019211Gallus gallus
 MAELENSG00000143194Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR024970  Maelstrom domain
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0046620 regulation of organ growth IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030849 autosome IDA
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0043186 P granule IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0071547 piP-body IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Maeltm1Bort/Maeltm1Bort,Spo11tm1Rdco/Spo11tm1Rdco
Genetic Background: involves: 129 * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Maeltm1Bort/Maeltm1Bort,Spo11tm1Rdco/Spo11tm1Rdco
Genetic Background: involves: 129 * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Maeltm1Bort/Maeltm1Bort,Spo11tm1Rdco/Spo11tm1Rdco
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Maeltm1Bort/Maeltm1Bort
Genetic Background: B6.129S4-Maeltm1Bort

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Maeltm1Bort/Maeltm1Bort
Genetic Background: B6.129S4-Maeltm1Bort

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Maeltm1Bort/Maeltm1Bort
Genetic Background: B6.129S4-Maeltm1Bort

 MP:0008878 abnormal DNA methylation during gametogenesis "any anomaly of the covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established" [GO:0043046]
Show

Allelic Composition: Maeltm1Bort/Maeltm1Bort
Genetic Background: B6.129S4-Maeltm1Bort

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036912 Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*  / complex
 ENSMUSG00000045662 Henmt1 / Q8CAE2 / Small RNA 2-O-methyltransferase / Q5T8I9* / HEN methyltransferase 1*  / reaction
 ENSMUSG00000041912 Tdrkh / Q80VL1 / Mus musculus tudor and KH domain containing protein (Tdrkh), transcript variant 4, mRNA. / Q9Y2W6* / tudor and KH domain containing*  / complex
 ENSMUSG00000054003 Tdrd9 / Q14BI7 / ATP-dependent RNA helicase TDRD9 / Q8NDG6* / tudor domain containing 9*  / complex






 

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