ENSMUSG00000040659


Mus musculus

Features
Gene ID: ENSMUSG00000040659
  
Biological name :Efhd2
  
Synonyms : EF-hand domain family member D2 / Efhd2
  
Possible biological names infered from orthology : Q96C19
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E1
Gene start: 141858142
Gene end: 141874920
  
Corresponding Affymetrix probe sets: 10518069 (MoGene1.0st)   1431339_a_at (Mouse Genome 430 2.0 Array)   1437478_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044502
NCBI entrez gene - 27984     See in Manteia.
MGI - MGI:106504
RefSeq - NM_025994
RefSeq Peptide - NP_080270
swissprot - Q8C845
Ensembl - ENSMUSG00000040659
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efhd2ENSDARG00000055759Danio rerio
 EFHD2ENSGALG00000038313Gallus gallus
 EFHD2ENSG00000142634Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efhd1 / Q9D4J1 / EF-hand domain-containing protein D1 / Q9BUP0* / EF-hand domain family member D1*ENSMUSG0000002625561


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Senp1tm1Wami/Senp1tm1Wami,Tg(Adipoq-cre)1Evdr/0
Genetic Background: B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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