ENSMUSG00000040797


Mus musculus

Features
Gene ID: ENSMUSG00000040797
  
Biological name :Iqsec3
  
Synonyms : IQ motif and SEC7 domain-containing protein 3 / Iqsec3 / Q3TES0
  
Possible biological names infered from orthology : IQ motif and Sec7 domain 3 / Q9UPP2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 121372933
Gene end: 121473678
  
Corresponding Affymetrix probe sets: 10547575 (MoGene1.0st)   1437912_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145523
Ensembl peptide - ENSMUSP00000038653
Ensembl peptide - ENSMUSP00000116317
Ensembl peptide - ENSMUSP00000120847
NCBI entrez gene - 243621     See in Manteia.
MGI - MGI:2677208
RefSeq - XM_006506113
RefSeq - NM_001033354
RefSeq - NM_001289685
RefSeq - XM_006506111
RefSeq - XM_006506112
RefSeq Peptide - NP_001276614
RefSeq Peptide - NP_001028526
swissprot - D6RHQ8
swissprot - Q3TES0
swissprot - A0A0N4SWH8
Ensembl - ENSMUSG00000040797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqsec3aENSDARG00000099850Danio rerio
 iqsec3bENSDARG00000093091Danio rerio
 IQSEC3ENSGALG00000012975Gallus gallus
 IQSEC3ENSG00000120645Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iqsec1 / Q8R0S2 / IQ motif and SEC7 domain-containing protein 1 / Q6DN90* / IQ motif and Sec7 domain 1*ENSMUSG0000003431236
Iqsec2 / IQ motif and Sec7 domain 2 / Q5JU85*ENSMUSG0000004111536
G3X9K3 / Arfgef1 / Brefeldin A-inhibited guanine nucleotide-exchange protein 1 / Q9Y6D6* / ADP ribosylation factor guanine nucleotide exchange factor 1*ENSMUSG0000006785118
A2A5R2 / Arfgef2 / Brefeldin A-inhibited guanine nucleotide-exchange protein 2 / Q9Y6D5* / ADP ribosylation factor guanine nucleotide exchange factor 2*ENSMUSG0000007458218
Cyth2 / P63034 / Cytohesin-2 / Q99418*ENSMUSG0000000326910
Cyth1 / Q9QX11 / Cytohesin-1 / Q15438*ENSMUSG0000001713210
Cyth3 / O08967 / Cytohesin-3 / O43739*ENSMUSG0000001800110
Cyth4 / Q80YW0 / Cytohesin-4 / Q9UIA0*ENSMUSG000000180089
Fbxo8 / Q9QZN3 / F-box only protein 8 / Q9NRD0* / F-box protein 8*ENSMUSG000000382067


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000904  Sec7 domain
 IPR011993  PH-like domain superfamily
 IPR023394  Sec7, C-terminal domain superfamily
 IPR033742  IQ motif and SEC7 domain-containing protein, PH domain
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0060077 inhibitory synapse IDA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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