ENSMUSG00000040852


Mus musculus
domainPlekhh2fermsuperfamilyproteinactinbindingcytoskeletonmembranemythpleckstrinhomologyph-likeacyl-coa-bindingcentralbandsecondregulationfilamentdepolymerizationnucleoplasmcytoplasmcytosolplasmanuclearbodylamellipodiumcorticalcellprojectionidentical

Features
Gene ID: ENSMUSG00000040852
  
Biological name :Plekhh2
  
Synonyms : Mus musculus pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 (Plekhh2), transcript variant 2, mRNA. / Plekhh2 / Q8C115
  
Possible biological names infered from orthology : pleckstrin homology, MyTH4 and FERM domain containing H2 / Q8IVE3
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 84511895
Gene end: 84622142
  
Corresponding Affymetrix probe sets: 10447190 (MoGene1.0st)   1427597_at (Mouse Genome 430 2.0 Array)   1444817_at (Mouse Genome 430 2.0 Array)   1460062_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039628
NCBI entrez gene - 213556     See in Manteia.
MGI - MGI:2146813
RefSeq - XM_017317382
RefSeq - NM_001357986
RefSeq - NM_177606
RefSeq - XM_011246357
RefSeq - XM_011246358
RefSeq - XM_017317381
RefSeq - XM_006523993
RefSeq - XM_006523994
RefSeq - XM_006523995
RefSeq - XM_006523996
RefSeq - XM_006523998
RefSeq Peptide - NP_808274
RefSeq Peptide - NP_001344915
swissprot - Q8C115
Ensembl - ENSMUSG00000040852
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekhh2ENSDARG00000040851Danio rerio
 PLEKHH2ENSGALG00000009947Gallus gallus
 Q8IVE3ENSG00000152527Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80TI1 / Plekhh1 / Pleckstrin homology domain-containing family H member 1 / Q9ULM0* / pleckstrin homology, MyTH4 and FERM domain containing H1*ENSMUSG0000006071646
Q8VCE9 / Plekhh3 / Mus musculus pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 (Plekhh3), transcript variant 2, mRNA. / Q7Z736* / pleckstrin homology, MyTH4 an...ENSMUSG0000003517211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
cellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationregulation of biological qualityactin filament-based processcellular component organizationcellular component organizationregulation of biological qualityregulation of biological qualityactin filament-based processactin filament-based process
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0030835 negative regulation of actin filament depolymerization IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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