ENSMUSG00000041323


Mus musculus

Features
Gene ID: ENSMUSG00000041323
  
Biological name :Ak7
  
Synonyms : adenylate kinase 7 / Ak7
  
Possible biological names infered from orthology : Q96M32
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 105705976
Gene end: 105782447
  
Corresponding Affymetrix probe sets: 10398130 (MoGene1.0st)   1430781_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043145
NCBI entrez gene - 78801     See in Manteia.
MGI - MGI:1926051
RefSeq - XM_006516391
RefSeq - NM_030187
RefSeq - XM_006516390
RefSeq Peptide - NP_084463
swissprot - F8WIC0
Ensembl - ENSMUSG00000041323
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ak7aENSDARG00000019001Danio rerio
 ak7bENSDARG00000017023Danio rerio
 AK7ENSGALG00000011093Gallus gallus
 AK7ENSG00000140057Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000850  Adenylate kinase/UMP-CMP kinase
 IPR007858  Dpy-30 motif
 IPR026867  Adenylate kinase 7
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0009142 nucleoside triphosphate biosynthetic process IEA
 molecular_functionGO:0004017 adenylate kinase activity IEA
 molecular_functionGO:0004127 cytidylate kinase activity IEA
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019205 nucleobase-containing compound kinase activity IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0001867 rhinitis "inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0002236 abnormal internal nares morphology "any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0010752 impaired mucociliary clearance "reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [MESH:E01.370.386.520, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ak7Tg(tetO-Hmox1)67Sami/Ak7Tg(tetO-Hmox1)67Sami
Genetic Background: FVB/N-Ak7Tg(tetO-Hmox1)67Sami

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
Show

Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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