ENSMUSG00000041347


Mus musculus

Features
Gene ID: ENSMUSG00000041347
  
Biological name :Bdkrb1
  
Synonyms : B1 bradykinin receptor / Bdkrb1 / Q61125
  
Possible biological names infered from orthology : bradykinin receptor B1 / P46663
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 105603085
Gene end: 105605428
  
Corresponding Affymetrix probe sets: 10398121 (MoGene1.0st)   1450586_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045335
Ensembl peptide - ENSMUSP00000138118
Ensembl peptide - ENSMUSP00000138216
NCBI entrez gene - 12061     See in Manteia.
MGI - MGI:88144
RefSeq - NM_007539
RefSeq Peptide - NP_031565
swissprot - Q0VBD7
swissprot - Q61125
swissprot - S4R1G8
Ensembl - ENSMUSG00000041347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bdkrb1ENSDARG00000020744Danio rerio
 BDKRB1ENSGALG00000020386Gallus gallus
 BDKRB1ENSG00000100739Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bdkrb2 / P32299 / B2 bradykinin receptor / P30411* / bradykinin receptor B2*ENSMUSG0000002107034
Agtr1a / P29754 / Type-1A angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000004911529
Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000005498829
Agtr2 / P35374 / Type-2 angiotensin II receptor / P50052* / angiotensin II receptor type 2*ENSMUSG0000006812228
Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*ENSMUSG0000004974126
Rxfp3 / Q8BGE9 / Relaxin-3 receptor 1 / Q9NSD7* / relaxin/insulin like family peptide receptor 3*ENSMUSG0000006073526
Aplnr / Q9WV08 / Apelin receptor / P35414*ENSMUSG0000004433825
Gpr25 / P0C5I1 / Probable G-protein coupled receptor 25 / O00155* / G protein-coupled receptor 25*ENSMUSG0000005275924
Gpr15 / Q0VDU3 / G-protein coupled receptor 15 / P49685*ENSMUSG0000004729323
Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*ENSMUSG0000004433722
Gpr182 / G protein-coupled receptor 182 / O15218*ENSMUSG0000005839622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000496  Bradykinin receptor family
 IPR001186  Bradykinin receptor B1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004947 bradykinin receptor activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

Allelic Composition: Bdkrb1tm1(BDKRB1)Jfh/Bdkrb1tm1(BDKRB1)Jfh
Genetic Background: involves: 129 * C57BL/6

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Isl2tm1Gan/Isl2tm1Gan
Genetic Background: Not Specified

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr