ENSMUSG00000041550


Mus musculus

Features
Gene ID: ENSMUSG00000041550
  
Biological name :Serpina5
  
Synonyms : P70458 / serine (or cysteine) peptidase inhibitor, clade A, member 5 / Serpina5
  
Possible biological names infered from orthology : P05154 / serpin family A member 5
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 104101113
Gene end: 104106137
  
Corresponding Affymetrix probe sets: 10398019 (MoGene1.0st)   1418813_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021495
NCBI entrez gene - 268591     See in Manteia.
MGI - MGI:107817
RefSeq - NM_172953
RefSeq - XM_006515916
RefSeq Peptide - NP_766541
swissprot - P70458
Ensembl - ENSMUSG00000041550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpina1ENSDARG00000090286Danio rerio
 serpina1lENSDARG00000090850Danio rerio
 serpina7ENSDARG00000087143Danio rerio
 si:ch211-186e20.2ENSDARG00000074712Danio rerio
 si:ch211-186e20.7ENSDARG00000077960Danio rerio
 zgc:174259ENSDARG00000091136Danio rerio
 ENSGALG00000028598Gallus gallus
 ENSGALG00000020388Gallus gallus
 ENSGALG00000020390Gallus gallus
 ENSGALG00000046409Gallus gallus
 SPIA1ENSGALG00000023070Gallus gallus
 SPIA4ENSGALG00000010969Gallus gallus
 P05154ENSG00000188488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D7D2 / Serpina9 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 / Q86WD7* / serpin family A member 9*ENSMUSG0000005826042
Serpina3i / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901441
Serpina3n / serine (or cysteine) peptidase inhibitor, clade A, member 3N / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000002109140
Serpina7 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 / P05543* / serpin family A member 7*ENSMUSG0000003127139
Serpina3k / serine (or cysteine) peptidase inhibitor, clade A, member 3K / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000005820739
Serpina11 / serpin family A member 11 / Q86U17*ENSMUSG0000006323239
P29621 / Serpina3c / Serine protease inhibitor A3C / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636139
Q80X76 / Serpina3f / Serine protease inhibitor A3F / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636339
Q03734 / Serpina3m / Serine protease inhibitor A3M / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901239
Q00898 / Serpina1e / serine (or cysteine) peptidase inhibitor, clade A, member 1E / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007284938
Serpina1c / serine (or cysteine) peptidase inhibitor, clade A, member 1C / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007901538
P07758 / Serpina1a / serine (or cysteine) peptidase inhibitor, clade A, member 1A / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000006636637
Q00897 / Serpina1d / serine (or cysteine) peptidase inhibitor, clade A, member 1D / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007117737
P22599 / Serpina1b / serine (or cysteine) preptidase inhibitor, clade A, member 1B / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007117837
Q6P4P1 / Serpina3a / serine (or cysteine) peptidase inhibitor, clade A, member 3A / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000004153636
Q8BYY9 / Serpina3b / serine (or cysteine) peptidase inhibitor, clade A, member 3B / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636436
Serpina3j / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901336
Q06770 / Serpina6 / serine (or cysteine) peptidase inhibitor, clade A, member 6 / P08185* / serpin family A member 6*ENSMUSG0000006080733
Q7TMF5 / Serpina12 / Serpin A12 / Q8IW75* / serpin family A member 12*ENSMUSG0000004156732
Q8R121 / Serpina10 / Protein Z-dependent protease inhibitor / Q9UK55* / serpin family A member 10*ENSMUSG0000006194730


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 cellular_componentGO:0002080 acrosomal membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 cellular_componentGO:0031094 platelet dense tubular network IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0036024 protein C inhibitor-TMPRSS7 complex IEA
 cellular_componentGO:0036025 protein C inhibitor-TMPRSS11E complex IEA
 cellular_componentGO:0036026 protein C inhibitor-PLAT complex IEA
 cellular_componentGO:0036027 protein C inhibitor-PLAU complex IEA
 cellular_componentGO:0036028 protein C inhibitor-thrombin complex IEA
 cellular_componentGO:0036029 protein C inhibitor-KLK3 complex IEA
 cellular_componentGO:0036030 protein C inhibitor-plasma kallikrein complex IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0097181 protein C inhibitor-coagulation factor V complex IEA
 cellular_componentGO:0097182 protein C inhibitor-coagulation factor Xa complex IEA
 cellular_componentGO:0097183 protein C inhibitor-coagulation factor XI complex IEA
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA
 molecular_functionGO:0032190 acrosin binding IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0005410 abnormal fertilization "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / complex / reaction






 

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