ENSMUSG00000042082


Mus musculus

Features
Gene ID: ENSMUSG00000042082
  
Biological name :Arsb
  
Synonyms : Arsb / arylsulfatase B
  
Possible biological names infered from orthology : P15848
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C3
Gene start: 93771630
Gene end: 93943016
  
Corresponding Affymetrix probe sets: 10406663 (MoGene1.0st)   10406672 (MoGene1.0st)   1429189_at (Mouse Genome 430 2.0 Array)   1429190_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088964
NCBI entrez gene - 11881     See in Manteia.
MGI - MGI:88075
RefSeq - NM_009712
RefSeq Peptide - NP_033842
swissprot - A0A0R4J138
Ensembl - ENSMUSG00000042082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARSBENSDARG00000108788Danio rerio
 ARSBENSGALG00000004438Gallus gallus
 ARSBENSG00000113273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arsj / Q8BM89 / Arylsulfatase J / Q5FYB0* / arylsulfatase family member J*ENSMUSG0000004656151
Arsi / Q32KI9 / Arylsulfatase I / Q5FYB1* / arylsulfatase family member I*ENSMUSG0000003641250
Galns / Q571E4 / N-acetylgalactosamine-6-sulfatase / P34059* / galactosamine (N-acetyl)-6-sulfatase*ENSMUSG0000001502724
Arsa / P50428 / Arylsulfatase A / P15289*ENSMUSG0000002262023
Arsg / Q3TYD4 / Arylsulfatase G / Q96EG1*ENSMUSG0000002060422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000917  Sulfatase, N-terminal
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR024607  Sulfatase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0010632 regulation of epithelial cell migration IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0051597 response to methylmercury IEA
 biological_processGO:0061580 colon epithelial cell migration IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003943 N-acetylgalactosamine-4-sulfatase activity IEA
 molecular_functionGO:0008484 sulfuric ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
The activation of arylsulfatases
CS/DS degradation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000346 broad head "a greater ear- to -ear distance resulting in the appearance of a wide face and a flattened snout" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000441 wide skull 
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000588 thick tail "a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0000958 peripheral nervous system degeneration "a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Rfngtm1Tfv/Rfng+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: En1tm1Alj/En1tm1Alj,Rfngtm1Tfv/Rfng+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Rfngtm1Tfv/Rfng+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm1Alj/En1tm1Alj,Rfngtm1Tfv/Rfng+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003958 heart valve hyperplasia "increased number of cells of the heart valves, leading to increased size or bulk" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:60214]
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Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0006045 mitral valve insufficiency "the mitral valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009415 skeletal muscle degeneration "pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

 MP:0011473 increased urine glycosaminoglycan level "greater in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [MGI:csmith]
Show

Allelic Composition: Cd4tm1Litt/Cd4tm1Nik,Tg(Lck-cre)3785Nik/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Arsbm1J/Arsbm1J
Genetic Background: C57BL/6J-Arsbm1J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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