ENSMUSG00000042265


Mus musculus

Features
Gene ID: ENSMUSG00000042265
  
Biological name :Trem1
  
Synonyms : Q9JKE2 / Trem1 / triggering receptor expressed on myeloid cells 1
  
Possible biological names infered from orthology : Q9NP99
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 48232768
Gene end: 48246924
  
Corresponding Affymetrix probe sets: 10445746 (MoGene1.0st)   1447284_at (Mouse Genome 430 2.0 Array)   1460282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038636
Ensembl peptide - ENSMUSP00000108877
NCBI entrez gene - 58217     See in Manteia.
MGI - MGI:1930005
RefSeq - XM_006524730
RefSeq - NM_021406
RefSeq - XM_006524726
RefSeq - XM_006524728
RefSeq - XM_006524729
RefSeq Peptide - NP_001334328
RefSeq Peptide - NP_067381
swissprot - Q14DT9
swissprot - Q9JKE2
Ensembl - ENSMUSG00000042265
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TREM1ENSG00000124731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trem3 / triggering receptor expressed on myeloid cells 3ENSMUSG0000004175424


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002374 cytokine secretion involved in immune response IGI
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0030593 neutrophil chemotaxis IGI
 biological_processGO:0042107 cytokine metabolic process IGI
 biological_processGO:0050755 chemokine metabolic process IGI
 biological_processGO:0070945 neutrophil mediated killing of gram-negative bacterium IGI
 biological_processGO:0072672 neutrophil extravasation IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0097110 scaffold protein binding ISO


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
DAP12 interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction






 

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