ENSMUSG00000042429


Mus musculus

Features
Gene ID: ENSMUSG00000042429
  
Biological name :Adora1
  
Synonyms : adenosine A1 receptor / Adora1 / Q60612
  
Possible biological names infered from orthology : P30542
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 134199223
Gene end: 134235431
  
Corresponding Affymetrix probe sets: 10357878 (MoGene1.0st)   1427331_at (Mouse Genome 430 2.0 Array)   1435495_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043522
Ensembl peptide - ENSMUSP00000083656
Ensembl peptide - ENSMUSP00000132105
Ensembl peptide - ENSMUSP00000140801
NCBI entrez gene - 11539     See in Manteia.
MGI - MGI:99401
RefSeq - XM_006529079
RefSeq - NM_001008533
RefSeq - NM_001039510
RefSeq - NM_001282945
RefSeq - NM_001291930
RefSeq Peptide - NP_001008533
RefSeq Peptide - NP_001034599
RefSeq Peptide - NP_001269874
RefSeq Peptide - NP_001278859
swissprot - Q60612
swissprot - A0A087WRW7
Ensembl - ENSMUSG00000042429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adora1aENSDARG00000070056Danio rerio
 adora1bENSDARG00000075694Danio rerio
 ADORA1ENSGALG00000000168Gallus gallus
 ADORA1ENSG00000163485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60613 / Adora2a / adenosine A2a receptor / P29274*ENSMUSG0000002017848
Q60614 / Adora2b / adenosine A2b receptor / P29275*ENSMUSG0000001850046
Adora3 / adenosine A3 receptor / P0DMS8*ENSMUSG0000000056244
Gpr119 / Q7TQP3 / G-protein coupled receptor 119 / Q8TDV5*ENSMUSG0000005120923
G3X8R9 / Tmigd3 / Transmembrane domain-containing protein TMIGD3 / P0DMS9* / transmembrane and immunoglobulin domain containing 3*ENSMUSG000000743445


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001068  Adenosine A1 receptor
 IPR001634  Adenosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001973 adenosine receptor signaling pathway IEA
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA
 biological_processGO:0002674 negative regulation of acute inflammatory response IEA
 biological_processGO:0002686 negative regulation of leukocyte migration IGI
 biological_processGO:0002793 positive regulation of peptide secretion IEA
 biological_processGO:0003093 regulation of glomerular filtration IMP
 biological_processGO:0006612 protein targeting to membrane IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014050 negative regulation of glutamate secretion IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032229 negative regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032244 positive regulation of nucleoside transport IEA
 biological_processGO:0032900 negative regulation of neurotrophin production IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0035814 negative regulation of renal sodium excretion IEA
 biological_processGO:0042321 negative regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043268 positive regulation of potassium ion transport IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0050890 cognition IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IEA
 biological_processGO:0051930 regulation of sensory perception of pain IMP
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IEA
 biological_processGO:0060079 excitatory postsynaptic potential IDA
 biological_processGO:0060087 relaxation of vascular smooth muscle IEA
 biological_processGO:0070256 negative regulation of mucus secretion IGI
 biological_processGO:0097756 negative regulation of blood vessel diameter IEA
 biological_processGO:1900453 negative regulation of long term synaptic depression IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0099055 integral component of postsynaptic membrane IEA
 cellular_componentGO:0099056 integral component of presynaptic membrane IEA
 molecular_functionGO:0001609 G-protein coupled adenosine receptor activity IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0001883 purine nucleoside binding IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0032795 heterotrimeric G-protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Adenosine P1 receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ightm2Mnz/Ightm2Mnz,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ightm2Mnz/Ightm2Mnz,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

Allelic Composition: Adora1tm1Rgrn/Adora1tm1Rgrn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cd81tm1Lvy/Cd81tm1Lvy
Genetic Background: either: (B6ByJ.129-Cd81tm1Lvy x CByJ.129-Cd81tm1Lvy)F1 or (CByJ.129-Cd81tm1Lvy x B6ByJ.129-Cd81tm1Lvy)F1

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cd81tm1Lvy/Cd81tm1Lvy
Genetic Background: either: (B6ByJ.129-Cd81tm1Lvy x CByJ.129-Cd81tm1Lvy)F1 or (CByJ.129-Cd81tm1Lvy x B6ByJ.129-Cd81tm1Lvy)F1

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0011297 absent tubuloglomerular feedback response "absence of the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa" [MGI:anna]
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Allelic Composition: Tnip1tm1.1Pcoh/Tnip1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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