ENSMUSG00000042476


Mus musculus

Features
Gene ID: ENSMUSG00000042476
  
Biological name :Abcb4
  
Synonyms : Abcb4 / P21440 / Phosphatidylcholine translocator ABCB4
  
Possible biological names infered from orthology : ATP binding cassette subfamily B member 4 / P21439
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 8893717
Gene end: 8959231
  
Corresponding Affymetrix probe sets: 10519578 (MoGene1.0st)   1449818_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003717
Ensembl peptide - ENSMUSP00000142425
NCBI entrez gene - 18670     See in Manteia.
MGI - MGI:97569
RefSeq - XM_006503554
RefSeq - NM_008830
RefSeq - XM_006503551
RefSeq - XM_006503552
RefSeq - XM_006503553
RefSeq Peptide - NP_032856
swissprot - P21440
swissprot - A0A0G2JDM4
Ensembl - ENSMUSG00000042476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb4ENSDARG00000010936Danio rerio
 ABCB1ENSGALG00000008912Gallus gallus
 ABCB4ENSG00000005471Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb1a / P21447 / Multidrug resistance protein 1A / ABCB1* / P08183* / ATP binding cassette subfamily B member 1*ENSMUSG0000004058474
Abcb1b / P06795 / ATP-binding cassette, sub-family B (MDR/TAP), member 1B / ABCB1* / P08183* / ATP binding cassette subfamily B member 1*ENSMUSG0000002897070
Abcb5 / B5X0E4 / ATP-binding cassette, sub-family B (MDR/TAP), member 5 / Q2M3G0* / ATP binding cassette subfamily B member 5*ENSMUSG0000007279151
Abcb11 / Q9QY30 / ATP-binding cassette, sub-family B (MDR/TAP), member 11 / O95342* / ATP binding cassette subfamily B member 11*ENSMUSG0000002704848


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030275  Multidrug resistance protein 3
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009914 hormone transport IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010046 response to mycotoxin IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014072 response to isoquinoline alkaloid IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032376 positive regulation of cholesterol transport IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032782 bile acid secretion IMP
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0033231 carbohydrate export IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0035633 maintenance of permeability of blood-brain barrier IEA
 biological_processGO:0036146 cellular response to mycotoxin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043215 daunorubicin transport IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045332 phospholipid translocation IEA
 biological_processGO:0046618 drug export IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0050892 intestinal absorption IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055088 lipid homeostasis IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060856 establishment of blood-brain barrier IEA
 biological_processGO:0061092 positive regulation of phospholipid translocation IEA
 biological_processGO:0071217 cellular response to external biotic stimulus IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071475 cellular hyperosmotic salinity response IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0097068 response to thyroxine IEA
 biological_processGO:0097327 response to antineoplastic agent IEA
 biological_processGO:1901557 response to fenofibrate IDA
 biological_processGO:1902065 response to L-glutamate IEA
 biological_processGO:1903413 cellular response to bile acid IEA
 biological_processGO:1903416 response to glycoside IEA
 biological_processGO:1904478 regulation of intestinal absorption IEA
 biological_processGO:1905231 cellular response to borneol IEA
 biological_processGO:1905232 cellular response to L-glutamate IEA
 biological_processGO:1905233 response to codeine IEA
 biological_processGO:1905235 response to quercetin IEA
 biological_processGO:1905237 response to cyclosporin A IEA
 biological_processGO:1990962 drug transport across blood-brain barrier IEA
 biological_processGO:1990963 establishment of blood-retinal barrier IEA
 biological_processGO:2001025 positive regulation of response to drug IEA
 biological_processGO:2001140 positive regulation of phospholipid transport IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0046581 intercellular canaliculus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008525 phosphatidylcholine transporter activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0090554 phosphatidylcholine-translocating ATPase activity IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0000202 abnormal circulating alkaline phosphatase level "anomalous concentration in the blood of this enzyme, which hydrolyzes orthophosphoric monoesters; low levels are seen in cases of hypophosphatasia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000203 abnormal circulating aspartate transaminase level "anomalous concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Tg(ABCG5/ABCG8)14-2Hobb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000610 cholestasis "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0001569 abnormal circulating bilirubin level "aberrant concentration in the blood of this yellow heme breakdown product " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

 MP:0001573 abnormal circulating alanine transaminase level "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0002138 abnormal liver/biliary system morphology "structural abnormality or aberrant development of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002139 abnormal liver/biliary system physiology "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Tg(ABCG5/ABCG8)14-2Hobb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

 MP:0002830 gallstones "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Tg(ABCG5/ABCG8)14-2Hobb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: H2-Ab1em1Ygch/H2-Ab1em1Ygch
Genetic Background: NOD/ShiLtJ-H2-Ab1em1Ygch

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0003046 liver cirrhosis "liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0003253 bile duct dilation "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

 MP:0003254 bile duct inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

 MP:0003256 biliary cirrhosis "liver damage to parenchymal cells due to obstruction of bile flow in the bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003328 portal hypertension "elevation of arterial blood pressure in the hepatic portal system, often a result of cirrhosis or of blockage of the portal vein" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Tg(ABCG5/ABCG8)14-2Hobb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Pemttm1J/Pemttm1J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Tg(ABCG5/ABCG8)14-2Hobb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Tg(ABCG5/ABCG8)14-2Hobb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: CAnNCrl.12P2(FVB)-Abcb4tm1Bor

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008837 increased transforming growth factor level "greater concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0008991 abnormal bile canaliculus morphology "any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008993 abnormal portal triad morphology "any structural anomaly of the three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Pemttm1J/Pemttm1J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0010877 abnormal trabecular bone volume "any anomaly in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0011584 increased alkaline phosphatase activity "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0011977 abnormal sodium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of sodium ions within the body or between a cell and its external environment" [MPD:Molly]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0012336 decreased vitamin D level "reduced level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: C.129P2-Abcb4tm1Bor

 MP:0012338 decreased bile salt level "reduced level of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Pemttm1J/Pemttm1J
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0020134 abnormal gallbladder size "an anomaly in the size of the gall bladder compared to average, the organ that serves as a storage reservoir for bile" [GOC:NV]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: FVB.129P2-Abcb4tm1Bor/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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