ENSMUSG00000042726


Mus musculus

Features
Gene ID: ENSMUSG00000042726
  
Biological name :Trafd1
  
Synonyms : Q3UDK1 / Trafd1 / TRAF-type zinc finger domain-containing protein 1
  
Possible biological names infered from orthology : O14545 / TRAF-type zinc finger domain containing 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 121371725
Gene end: 121385632
  
Corresponding Affymetrix probe sets: 10533304 (MoGene1.0st)   1428346_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113910
Ensembl peptide - ENSMUSP00000115159
Ensembl peptide - ENSMUSP00000144108
Ensembl peptide - ENSMUSP00000143426
Ensembl peptide - ENSMUSP00000118351
Ensembl peptide - ENSMUSP00000117239
Ensembl peptide - ENSMUSP00000047475
NCBI entrez gene - 231712     See in Manteia.
MGI - MGI:1923551
RefSeq - XM_011248197
RefSeq - XM_006530302
RefSeq - XM_017320867
RefSeq - XM_017320866
RefSeq - XM_017320865
RefSeq - NM_001163470
RefSeq - NM_172275
RefSeq - XM_017320868
RefSeq - XM_017320864
RefSeq Peptide - NP_758479
RefSeq Peptide - NP_001156942
swissprot - Q3UDK1
swissprot - D3Z5F4
swissprot - A0A0G2JG49
swissprot - A0A0J9YUC2
swissprot - D3YWU1
swissprot - D3YX05
Ensembl - ENSMUSG00000042726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trafd1ENSDARG00000075123Danio rerio
 TRAFD1ENSGALG00000043208Gallus gallus
 O14545ENSG00000135148Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Xaf1 / Q5NBU8 / XIAP associated factor 1 / Q6GPH4*ENSMUSG0000004048311


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR010919  SAND-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0045824 negative regulation of innate immune response IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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