ENSMUSG00000042761


Mus musculus

Features
Gene ID: ENSMUSG00000042761
  
Biological name :Mrap2
  
Synonyms : D3Z1Q2 / Melanocortin-2 receptor accessory protein 2 / Mrap2
  
Possible biological names infered from orthology : Q96G30
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.1
Gene start: 87144306
Gene end: 87184045
  
Corresponding Affymetrix probe sets: 10587633 (MoGene1.0st)   1436274_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046271
Ensembl peptide - ENSMUSP00000108774
Ensembl peptide - ENSMUSP00000135904
NCBI entrez gene - 244958     See in Manteia.
MGI - MGI:3609239
RefSeq - XM_006511180
RefSeq - NM_001101482
RefSeq - NM_001177731
RefSeq - XM_006511177
RefSeq - XM_006511178
RefSeq - XM_006511179
RefSeq - XM_006511173
RefSeq - XM_006511174
RefSeq - XM_006511175
RefSeq - XM_006511176
RefSeq Peptide - NP_001094952
RefSeq Peptide - NP_001171202
swissprot - D3Z1Q2
Ensembl - ENSMUSG00000042761
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F8W4H9ENSDARG00000074763Danio rerio
 mrap2bENSDARG00000103050Danio rerio
 MRAP2ENSGALG00000015838Gallus gallus
 MRAP2ENSG00000135324Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028111  Melanocortin-2 receptor accessory protein family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006112 energy reserve metabolic process IMP
 biological_processGO:0007631 feeding behavior IMP
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IMP
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:0097009 energy homeostasis IMP
 biological_processGO:0106071 positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0031780 corticotropin hormone receptor binding ISO
 molecular_functionGO:0031781 type 3 melanocortin receptor binding ISO
 molecular_functionGO:0031782 type 4 melanocortin receptor binding IDA
 molecular_functionGO:0031783 type 5 melanocortin receptor binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0070996 type 1 melanocortin receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Mrap2tm1.2Maj/Mrap2tm1.2Maj,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm1Lowl/Mc4r+,Mrap2tm1.1Maj/Mrap2+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Mrap2tm1.1Maj/Mrap2tm1.1Maj
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Mrap2tm1.2Maj/Mrap2tm1.2Maj,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011958 increased compensatory feeding amount "increased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Cd22tm3Lnit/Cd22tm3Lnit
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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