ENSMUSG00000043050


Mus musculus

Features
Gene ID: ENSMUSG00000043050
  
Biological name :Tnp2
  
Synonyms : Nuclear transition protein 2 / P11378 / Tnp2
  
Possible biological names infered from orthology : Q05952 / transition protein 2
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 10787936
Gene end: 10788660
  
Corresponding Affymetrix probe sets: 10437673 (MoGene1.0st)   1422419_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053078
NCBI entrez gene - 21959     See in Manteia.
MGI - MGI:98785
RefSeq - NM_013694
RefSeq Peptide - NP_038722
swissprot - P11378
Ensembl - ENSMUSG00000043050
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNP2ENSG00000178279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000678  Nuclear transition protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007339 binding of sperm to zona pellucida IGI
 biological_processGO:0007340 acrosome reaction IMP
 biological_processGO:0007341 penetration of zona pellucida IMP
 biological_processGO:0010954 positive regulation of protein processing IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IGI
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IMP
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0001673 male germ cell nucleus TAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1atm1Drab/Hist1h1a+,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Ais/Hist1h1ttm1Ais,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J * CD-1

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
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Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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