ENSMUSG00000043953


Mus musculus

Features
Gene ID: ENSMUSG00000043953
  
Biological name :Ccrl2
  
Synonyms : C-C chemokine receptor-like 2 / Ccrl2 / O35457
  
Possible biological names infered from orthology : C-C motif chemokine receptor like 2 / O00421
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F2
Gene start: 111054486
Gene end: 111057519
  
Corresponding Affymetrix probe sets: 10597279 (MoGene1.0st)   1427736_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107519
Ensembl peptide - ENSMUSP00000143105
Ensembl peptide - ENSMUSP00000143116
NCBI entrez gene - 54199     See in Manteia.
MGI - MGI:1920904
RefSeq - NM_001302376
RefSeq - NM_001302377
RefSeq - NM_017466
RefSeq Peptide - NP_001289305
RefSeq Peptide - NP_001289306
RefSeq Peptide - NP_059494
swissprot - O35457
swissprot - A0A0G2JFB5
Ensembl - ENSMUSG00000043953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01053221.1ENSDARG00000058774Danio rerio
 CU633991.1ENSDARG00000086314Danio rerio
 CCRL2ENSG00000121797Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0016493 C-C chemokine receptor activity ISS
 molecular_functionGO:0042379 chemokine receptor binding IPI
 molecular_functionGO:0048020 CCR chemokine receptor binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002148 immune system: hypersensitivity "immune response that results in tissue injury" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptgs1tm1Unc/Ptgs1tm1Unc,Ptgs2tm1Unc/Ptgs2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000071005 Ccl19 / O70460 / C-C motif chemokine 19 / Q99731* / C-C motif chemokine ligand 19*  / complex / reaction






 

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