ENSMUSG00000044350


Mus musculus

Features
Gene ID: ENSMUSG00000044350
  
Biological name :Lacc1
  
Synonyms : Lacc1 / Laccase domain-containing protein 1 / Q8BZT9
  
Possible biological names infered from orthology : AL512506.3 / laccase domain containing 1 / Q8IV20
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D3
Gene start: 77024200
Gene end: 77036904
  
Corresponding Affymetrix probe sets: 10421697 (MoGene1.0st)   1455263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059173
Ensembl peptide - ENSMUSP00000135628
NCBI entrez gene - 210808     See in Manteia.
MGI - MGI:2445077
RefSeq - NM_172488
RefSeq Peptide - NP_766076
swissprot - H3BL27
swissprot - Q8BZT9
Ensembl - ENSMUSG00000044350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lacc1ENSDARG00000076914Danio rerio
 ENSGALG00000016969Gallus gallus
 AL512506.3ENSG00000281883Homo sapiens
 LACC1ENSG00000179630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003730  Multi-copper polyphenol oxidoreductase
 IPR011324  Cytotoxic necrotizing factor-like, catalytic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005777 peroxisome ISO
 molecular_functionGO:0005507 copper ion binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Lacc1em3Arkr/Lacc1em3Arkr
Genetic Background: C57BL/6NTac-Lacc1em3Arkr

Allelic Composition: Lacc1em4Arkr/Lacc1em4Arkr
Genetic Background: C57BL/6NTac-Lacc1em4Arkr

Allelic Composition: Lacc1em1Arkr/Lacc1em1Arkr
Genetic Background: C57BL/6NTac-Lacc1em1Arkr

Allelic Composition: Lacc1em2Arkr/Lacc1em2Arkr
Genetic Background: C57BL/6NTac-Lacc1em2Arkr

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Lacc1em3Arkr/Lacc1em3Arkr
Genetic Background: C57BL/6NTac-Lacc1em3Arkr

Allelic Composition: Lacc1em4Arkr/Lacc1em4Arkr
Genetic Background: C57BL/6NTac-Lacc1em4Arkr

Allelic Composition: Lacc1em1Arkr/Lacc1em1Arkr
Genetic Background: C57BL/6NTac-Lacc1em1Arkr

Allelic Composition: Lacc1em2Arkr/Lacc1em2Arkr
Genetic Background: C57BL/6NTac-Lacc1em2Arkr

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Lacc1em3Arkr/Lacc1em3Arkr
Genetic Background: C57BL/6NTac-Lacc1em3Arkr

Allelic Composition: Lacc1em4Arkr/Lacc1em4Arkr
Genetic Background: C57BL/6NTac-Lacc1em4Arkr

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Lacc1em1Arkr/Lacc1em1Arkr
Genetic Background: C57BL/6NTac-Lacc1em1Arkr

Allelic Composition: Lacc1em2Arkr/Lacc1em2Arkr
Genetic Background: C57BL/6NTac-Lacc1em2Arkr

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lacc1em1Arkr/Lacc1em1Arkr
Genetic Background: C57BL/6NTac-Lacc1em1Arkr

Allelic Composition: Lacc1em2Arkr/Lacc1em2Arkr
Genetic Background: C57BL/6NTac-Lacc1em2Arkr

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Lacc1em3Arkr/Lacc1em3Arkr
Genetic Background: C57BL/6NTac-Lacc1em3Arkr

Allelic Composition: Lacc1em4Arkr/Lacc1em4Arkr
Genetic Background: C57BL/6NTac-Lacc1em4Arkr

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: X/Eif2s3yem#Asah
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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