ENSMUSG00000044667


Mus musculus

Features
Gene ID: ENSMUSG00000044667
  
Biological name :Plppr4
  
Synonyms : Phospholipid phosphatase-related protein type 4 / Plppr4 / Q7TME0
  
Possible biological names infered from orthology : phospholipid phosphatase related 4 / Q7Z2D5
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G1
Gene start: 117319139
Gene end: 117360876
  
Corresponding Affymetrix probe sets: 10501754 (MoGene1.0st)   1427247_at (Mouse Genome 430 2.0 Array)   1434685_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143753
Ensembl peptide - ENSMUSP00000052306
NCBI entrez gene - 229791     See in Manteia.
MGI - MGI:106530
RefSeq - NM_177664
RefSeq Peptide - NP_808332
swissprot - A0A0G2JGY9
swissprot - Q7TME0
Ensembl - ENSMUSG00000044667
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plppr4aENSDARG00000079671Danio rerio
 plppr4bENSDARG00000078755Danio rerio
 PLPPR4ENSGALG00000025896Gallus gallus
 PLPPR4ENSG00000117600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plppr3 / phospholipid phosphatase related 3 / Q6T4P5*ENSMUSG0000003583545
Plppr2 / Q8VCY8 / Phospholipid phosphatase-related protein type 2 / Q96GM1* / phospholipid phosphatase related 2*ENSMUSG0000004056317
Plppr1 / Q8BFZ2 / Phospholipid phosphatase-related protein type 1 / Q8TBJ4* / phospholipid phosphatase related 1*ENSMUSG0000006344616
Plppr5 / Q8BJ52 / Phospholipid phosphatase-related protein type 5 / Q32ZL2* / phospholipid phosphatase related 5*ENSMUSG0000003334214
Plpp1 / Q61469 / Phospholipid phosphatase 1 / O14494*ENSMUSG0000002175911
Plpp3 / Q99JY8 / Phospholipid phosphatase 3 / O14495* / AC119674.2*ENSMUSG0000002851710
Plpp2 / Q9DAX2 / phospholipid phosphatase 2 / O43688*ENSMUSG000000521519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR028684  Phospholipid phosphatase-related protein type 4
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006644 phospholipid metabolic process IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0046839 phospholipid dephosphorylation IEA
 biological_processGO:0048839 inner ear development IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008195 phosphatidate phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042577 lipid phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Plppr4tm1Roni/Plppr4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

Allelic Composition: Plppr4tm1Roni/Plppr4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

Allelic Composition: Plppr4tm2.1Roni/Plppr4tm2.1Roni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plppr4tm1Roni/Plppr4tm1Roni,Lpar2tm1Jch/Lpar2tm1Jch
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu,Aldh1a3tm1Gdu/Aldh1a3tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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