ENSMUSG00000044701


Mus musculus

Features
Gene ID: ENSMUSG00000044701
  
Biological name :Il27
  
Synonyms : Il27 / Interleukin-27 subunit alpha / Q8K3I6
  
Possible biological names infered from orthology : interleukin 27 / Q8NEV9
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126589010
Gene end: 126594941
  
Corresponding Affymetrix probe sets: 10567987 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000054637
NCBI entrez gene - 246779     See in Manteia.
MGI - MGI:2384409
RefSeq - NM_145636
RefSeq - XM_006507857
RefSeq Peptide - NP_663611
swissprot - Q8K3I6
Ensembl - ENSMUSG00000044701
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL27ENSG00000197272Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026207  Interleukin-27 alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IGI
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042129 regulation of T cell proliferation IDA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045625 regulation of T-helper 1 cell differentiation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045523 interleukin-27 receptor binding IDA


Pathways (from Reactome)
Pathway description
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm1Les/Lattm1Les,Lcp2tm5(Lat/Lcp2)Gak/Lcp2tm5(Lat/Lcp2)Gak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Lcp2tm5(Lat/Lcp2)Gak/Lcp2tm5(Lat/Lcp2)Gak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm1Les/Lattm1Les,Lcp2tm5(Lat/Lcp2)Gak/Lcp2tm5(Lat/Lcp2)Gak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt7apx-2J/Wnt7apx-2J
Genetic Background: B6;C3Fe-Wnt7apx-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex
 ENSMUSG00000007888 Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*  / complex
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex / reaction
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex






 

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