ENSMUSG00000045019


Mus musculus

Features
Gene ID: ENSMUSG00000045019
  
Biological name :Acer1
  
Synonyms : Acer1 / alkaline ceramidase 1 / Q8R4X1
  
Possible biological names infered from orthology : Q8TDN7
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 56953490
Gene end: 56982126
  
Corresponding Affymetrix probe sets: 10452202 (MoGene1.0st)   1439183_at (Mouse Genome 430 2.0 Array)   1450825_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062037
NCBI entrez gene - 171168     See in Manteia.
MGI - MGI:2181962
RefSeq - NM_175731
RefSeq Peptide - NP_783858
swissprot - Q8R4X1
Ensembl - ENSMUSG00000045019
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acer1ENSDARG00000010347Danio rerio
 ACER1ENSGALG00000001592Gallus gallus
 ACER1ENSG00000167769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acer2 / Q8VD53 / alkaline ceramidase 2 / Q5QJU3*ENSMUSG0000003800728


Protein motifs (from Interpro)
Interpro ID Name
 IPR008901  Ceramidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IDA
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0010446 response to alkaline pH IEA
 biological_processGO:0019216 regulation of lipid metabolic process IDA
 biological_processGO:0030148 sphingolipid biosynthetic process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0046512 sphingosine biosynthetic process IEA
 biological_processGO:0046514 ceramide catabolic process IDA
 biological_processGO:0071277 cellular response to calcium ion IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
 molecular_functionGO:0017040 N-acylsphingosine amidohydrolase activity ISO
 molecular_functionGO:0071633 dihydroceramidase activity IEA
 molecular_functionGO:0102121 ceramidase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps/Nci

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Ccdc62em1Jxia/Ccdc62em1Jxia
Genetic Background: C57BL/6-Ccdc62em1Jxia

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ccdc62em1Jxia/Ccdc62em1Jxia
Genetic Background: C57BL/6-Ccdc62em1Jxia

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0003941 abnormal skin development "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0008860 abnormal hair cycle telogen phase "anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and preceeds hair loss" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009441 delayed skin barrier formation "slowed progression in the establishment of the ability of the skin to regulate water loss" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009535 abnormal skin sebaceous gland morphology "any structural anomaly of the holocrine glands of the dermis that secrete sebum into the hair follicles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009602 abnormal keratohyalin granule morphology "any structural anomaly of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0009793 sebaceous gland hypertrophy "increase in the bulk size of the sebum secreting glands of the hair shaft due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0009823 abnormal sphingomyelin level "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0010682 abnormal hair follicle infundibulum morphology "any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface" [PMID:19211055]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0010683 dilated hair follicle infundibulum "the luminal space of the hair follicle infundibulum is increased in volume or area, sometimes with an increase of contained fluid or sebum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0011194 abnormal hair follicle physiology "any functional anomaly of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500, MGI:mnk]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0012232 abnormal ceramide level 
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0013375 abnormal sebocyte morphology "any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [MGI:Anna, PMID:19944183]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0013420 decreased CD5-positive gamma-delta T cell number "reduction in the number of CD5+ gamma-delta T cells" [IMPC:Saran]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0020117 decreased sphingosine level "decreased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid" [GOC:NV, http://en.wikipedia.org/wiki/Sphingosine]
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Allelic Composition: Acer1tm1a(EUCOMM)Wtsi/Acer1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acer1tm1a(EUCOMM)Wtsi

 MP:0030570 abnormal piliary canal morphology "any structural anomaly of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft" [PMID:19211055, UBERON:0035610]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg
Genetic Background: C57BL/6-Acer1tm1(KOMP)Vlcg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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