ENSMUSG00000045539


Mus musculus

Features
Gene ID: ENSMUSG00000045539
  
Biological name :Sprr3
  
Synonyms : O09116 / Small proline-rich protein 3 / Sprr3
  
Possible biological names infered from orthology : Q9UBC9
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 92456502
Gene end: 92458720
  
Corresponding Affymetrix probe sets: 10499896 (MoGene1.0st)   1422401_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056287
NCBI entrez gene - 20766     See in Manteia.
MGI - MGI:1330237
RefSeq - NM_011478
RefSeq - NM_001204427
RefSeq Peptide - NP_001191356
RefSeq Peptide - NP_035608
swissprot - O09116
Ensembl - ENSMUSG00000045539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPRR3ENSG00000163209Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62267 / Sprr1b / Cornifin-B ENSMUSG0000004845530
Q62266 / Sprr1a / Cornifin-A ENSMUSG0000005035930


Protein motifs (from Interpro)
Interpro ID Name
 IPR026075  Small proline-rich protein/late cornified envelope protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018149 peptide cross-linking IBA
 biological_processGO:0030216 keratinocyte differentiation IBA
 biological_processGO:0031424 keratinization IEA
 cellular_componentGO:0001533 cornified envelope IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0005198 structural molecule activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm4.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm4.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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