ENSMUSG00000045733


Mus musculus

Features
Gene ID: ENSMUSG00000045733
  
Biological name :Sprn
  
Synonyms : Q8BWU1 / Shadow of prion protein / Sprn
  
Possible biological names infered from orthology : Q5BIV9
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F4
Gene start: 140150628
Gene end: 140154877
  
Corresponding Affymetrix probe sets: 10568948 (MoGene1.0st)   1459019_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147870
Ensembl peptide - ENSMUSP00000053901
NCBI entrez gene - 212518     See in Manteia.
MGI - MGI:3582583
RefSeq - NM_183147
RefSeq Peptide - NP_898970
swissprot - A0A1B0GSB6
swissprot - Q8BWU1
Ensembl - ENSMUSG00000045733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPRNENSG00000203772Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029238  Shadow of prion protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006606 protein import into nucleus IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 molecular_functionGO:0003676 nucleic acid binding IDA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/NCr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/NCr

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/NCr

 MP:0003314 dysmetria "an inability to control the range of motion, typified by under- or over-shooting the intended position with the hand, arm, leg or eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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