ENSMUSG00000046108


Mus musculus

Features
Gene ID: ENSMUSG00000046108
  
Biological name :Il17c
  
Synonyms : Il17c / interleukin-17C
  
Possible biological names infered from orthology : Q9P0M4
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 122422020
Gene end: 122423639
  
Corresponding Affymetrix probe sets: 10576115 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000056008
NCBI entrez gene - 234836     See in Manteia.
MGI - MGI:2446486
RefSeq - NM_145834
RefSeq Peptide - NP_665833
swissprot - A0A0R4J0P4
Ensembl - ENSMUSG00000046108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il17cENSDARG00000057180Danio rerio
 IL17CENSGALG00000028465Gallus gallus
 IL17CENSG00000124391Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il25 / interleukin 25 / Q9H293*ENSMUSG0000004077024


Protein motifs (from Interpro)
Interpro ID Name
 IPR010345  Interleukin-17 family
 IPR020440  Interleukin-17, chordata
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005125 cytokine activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-17 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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