ENSMUSG00000046518


Mus musculus

Features
Gene ID: ENSMUSG00000046518
  
Biological name :Ferd3l
  
Synonyms : Fer3-like protein / Ferd3l / Q923Z4
  
Possible biological names infered from orthology : Fer3 like bHLH transcription factor / Q96RJ6
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A3
Gene start: 33928425
Gene end: 33929310
  
Corresponding Affymetrix probe sets: 10395317 (MoGene1.0st)   1422410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058994
NCBI entrez gene - 114712     See in Manteia.
MGI - MGI:2150010
RefSeq - NM_033522
RefSeq Peptide - NP_277057
swissprot - Q923Z4
Ensembl - ENSMUSG00000046518
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ferd3lENSDARG00000092160Danio rerio
 FERD3LENSGALG00000010862Gallus gallus
 FERD3LENSG00000146618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptf1a / Q9QX98 / pancreas specific transcription factor, 1a / Q7RTS3*ENSMUSG0000002673530


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0033504 floor plate development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0048468 cell development IMP
 biological_processGO:0050767 regulation of neurogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm3.1Shn/Lrrk2tm3.1Shn
Genetic Background: involves: 129 * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm3.1Shn/Lrrk2tm3.1Shn
Genetic Background: involves: 129 * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm3.1Shn/Lrrk2tm3.1Shn
Genetic Background: involves: 129 * C57BL/6

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
Show

Allelic Composition: Lrrk2tm3.1Shn/Lrrk2tm3.1Shn
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr