ENSMUSG00000046697


Mus musculus

Features
Gene ID: ENSMUSG00000046697
  
Biological name :Enpp7
  
Synonyms : ectonucleotide pyrophosphatase/phosphodiesterase 7 / Enpp7
  
Possible biological names infered from orthology : Q6UWV6
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 118988188
Gene end: 118992841
  
Corresponding Affymetrix probe sets: 10383047 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000090027
Ensembl peptide - ENSMUSP00000101880
NCBI entrez gene - 238011     See in Manteia.
MGI - MGI:3027917
RefSeq - NM_001030291
RefSeq - XM_006533258
RefSeq Peptide - NP_001025462
swissprot - D3Z6V6
swissprot - A2A5N7
Ensembl - ENSMUSG00000046697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 enpp7.1ENSDARG00000053526Danio rerio
 enpp7.2ENSDARG00000053525Danio rerio
 ENPP7ENSGALG00000013743Gallus gallus
 ENPP7ENSG00000182156Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Enpp5 / Q9EQG7 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 5 (Enpp5), transcript variant 7, mRNA. / Q9UJA9* / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)*ENSMUSG0000002396032
Enpp1 / ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 / P22413* / ectonucleotide pyrophosphatase/phosphodiesterase 1*ENSMUSG0000003737031
Enpp3 / Q6DYE8 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Alkaline phosphodiesterase I Nucleotide pyrophosphatase / O14638* / ectonucleotide pyrophosphatase/phosphod...ENSMUSG0000001998928
Enpp2 / Q9R1E6 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 / Q13822* / ectonucleotide pyrophosphatase/phosphodiesterase 2*ENSMUSG0000002242528
Enpp4 / Q8BTJ4 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4 (Enpp4), transcript variant 2, mRNA. / Q9Y6X5* / ectonucleotide pyrophosphatase/phosphodiesterase 4*ENSMUSG0000002396128
Enpp6 / Q8BGN3 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 / Q6UWR7* / ectonucleotide pyrophosphatase/phosphodiesterase 6*ENSMUSG0000003817326


Protein motifs (from Interpro)
Interpro ID Name
 IPR002591  Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR029895  Ectonucleotide pyrophosphatase/phosphodiesterase family member 7


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006684 sphingomyelin metabolic process IEA
 biological_processGO:0006685 sphingomyelin catabolic process ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005902 microvillus IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity ISO


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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